💊Drug Induced pancreatitis (DIP) by @AshkarMotaz from @WUGastro soon returning as @MayoClinicGIHep staff #IMPACT #gitwitter

🥇See tweet 5 for the current classification dx!

📚Hx of DIP: Understanding of DIP has evolved since it was first described in 1950s-60s on case reports 🥇First drug-induced acute pancreatitis (AP) classification came out in '96

Subclassified as - definitive, probable, and possible DIP

Limitations of '96 classification:

1⃣DIP is UNCOMMON
2⃣DIP NOT different from AP 2/2 other causes
4⃣Drug re-challenge often not possible

🔮Pancreatic cysts: What's in the Juice by #YanBi from #MayoFL #IMPACT #gitwitter

🎯Pancreatic Cysts Incidence 📈with ↑imaging

🌟90% of P-Cysts are IPMNs (Intraductal Papillary Mucinous Neoplasms)
-70% IPMNs are BD-IPMN (branch duct)
-30% IPMNs are MD-IPMN (main duct) 🔮Benign cysts (observation/drainage/sx)
- Pseudocyst
- Serous cystadenoma

⁉️Pre-malignant (observation/sx)
- IPMN
- MCN (mucinous cystic neoplams)

🦀Malignant (sx)
- Cystic neuroendocrine tumor (CNET)
- Solid pseudopapillary neoplasm (SPN)
- Cystic degeneration of PDAC

🌟Pancreatic cancer (PC) Screening by @MajumderShounak #IMPACT #gitwitter

Why care about screening for PC?
10th leading cancer 🦀diagnosis in 🇺🇸 but 3rd leading cancer☠️with 5-year survival is only 11%

🎯Current recommendations suggest against PC screening unless "high-risk" Define "High-risk individual" (HRI)?
1⃣Age
2⃣Fam hx of PC (dx age, relationship)
3⃣Germline mutations

‼️Familial PC = ≥2 first-degree relatives (FDR)
☠️If 2 FDR 6x risk
☠️If 3 FDR 32x risk

🦀Genetic mutations assoc with PC (5.5% cases) - CDKN2A, TP53, MLH1, BRCA2, ATM,
BRCA1