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David Faleck Profile picture
David Faleck
@DavidFaleckMD
Gastroenterologist @sloan_kettering. Focused on IBD, dysplasia, cancer, checkpoint inhibitors, immune-related toxicities
Feb 3 • 4 tweets • 3 min read
@DrJordanAxelrad @DCharabaty @MondayNightIBD @abbvie @JNJInnovMed @TakedaPharma @JHashashMD @fudmanMD @FunchainMD @ibdtweets @IBD_JohnD @EugeneYenMD @JeanFredericCo1 @IBDimmunology @DrsMeena @clivejmiranda @datadriven_tdoc @IBD_FloMD @MLongMD @DavidHudesmanMD @shannonchangmd @SimonHongMD @HolmerMd @DrMikeDolinger @ryanungaro @AdamFayeMD @EdwardLoftus2 @EdBarnesMD @BenClickMD @tommasoparigi @AndresYarur @ownyourcrohns @JustinFieldMD @MeganMurphyGI @AmyStewartNP @LindsayClarkeMD @KDeFelice_IBD @AimenKhanMD @EdithHoMD @IBD_DrEMF @IBDPharmD @ElisaBodenIBDMD @SalamBachour @RahulSDalalMD @md_ayanna @ibddoctor @DrPhil_Gu @AGA_Gastro @MichaelKappel12 @JAMADerm Great case. No one right answer here — and lots of different data points that inform how we think about this tough dilemma. I'll summarize a few of my considerations: @DrJordanAxelrad @DCharabaty @MondayNightIBD @abbvie @JNJInnovMed @TakedaPharma @JHashashMD @fudmanMD @FunchainMD @ibdtweets @IBD_JohnD @EugeneYenMD @JeanFredericCo1 @IBDimmunology @DrsMeena @clivejmiranda @datadriven_tdoc @IBD_FloMD @MLongMD @DavidHudesmanMD @shannonchangmd @SimonHongMD @HolmerMd @DrMikeDolinger @ryanungaro @AdamFayeMD @EdwardLoftus2 @EdBarnesMD @BenClickMD @tommasoparigi @AndresYarur @ownyourcrohns @JustinFieldMD @MeganMurphyGI @AmyStewartNP @LindsayClarkeMD @KDeFelice_IBD @AimenKhanMD @EdithHoMD @IBD_DrEMF @IBDPharmD @ElisaBodenIBDMD @SalamBachour @RahulSDalalMD @md_ayanna @ibddoctor @DrPhil_Gu @AGA_Gastro @MichaelKappel12 @JAMADerm 1/ Early on ICI MAY be most important time period to avoid blunting immune activation.
Baseline (pubmed.ncbi.nlm.nih.gov/30125216/) and early (pubmed.ncbi.nlm.nih.gov/34376536/) steroids seem detrimental.
Limited data on non-steroid immunosuppressives in the baseline setting.