David Juncker Profile picture
Biomedical engineer, scientist, curious, not a fan of orthodoxies, covid19 rapid testing, twitter dyslexia. My opinions
Jan 12, 2022 8 tweets 3 min read
Is this groundhog day?

'Experts' were wrong on rapid tests all along, first ignoring them, then rejecting them, and only accepting them with #omicron.

Now some reject throat swabbing because it is not how tests were approved by @GovCanHealth

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theglobeandmail.com/canada/article… Regulatory approval logic commands us to not use the BTNX test shown in the image 👆 because it is not approved for self-testing, nor for asymptomatic testing, as of today. 👇

Yet it is widely distributed and used for self-testing 🤔
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Jan 12, 2022 4 tweets 3 min read
Swab the throat for your rapid test, yes or no?
YES : @IsraelMOH ctvnews.ca/health/coronav…
NO @FDA and @GovCanHealth
ctvnews.ca/health/coronav…

A risk benefit-analysis strongly supports YES. High risk of false negatives with nose swabbing, yet no reports of false positives owing to off-label throat swabbing.

Video demo on Tiktok with >400K❤️tiktok.com/@alisonhallrep…
Jan 11, 2022 12 tweets 5 min read
🧵Are rapid tests working with #omicron and how to use them?

The analytical performance of RAT vs PCR seems unchanged, but the capacity to detect infectious cases when used as instructed appears to be lower.

Two contradictory preprints, and anecdotes feed this analysis.
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Abbott BinaxNow vs PCR,
Both nose swabbing, RAT first, then PCR

Excellent concordance up to CT<30, roughly the threshold where samples remain infectious when incubated in cell culture.
medrxiv.org/content/10.110…

➡️RAT Analytical performance is preserved with omicron
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