1/ When bubbles settle on the surface of the urine it indicates disease of the kidneys-Hippocrates

In the day, urinary exam was so crucial, the urine flask was as much a symbol of a physician as today's white🥼!

🧵Is proteinuria a worthy rival to GFR?
#Nephmadness #primarycare 2/
*⃣Normal urinary protein excretion is <150mg/d and comprises mainly Tamm-Horsfall proteins, with very little albumin (5-10mg/d)

*⃣ We don't understand what happens to albumin in the kidney 💯

*⃣ But overall the degree of albuminuria is a ⚖️of filtration + reabsorption 👇

1/ Monitoring eGFR in CKD is almost a reflex🦵!

But how did we get here?
What are we trying to assess?
And how does eGFR help?

#NephMadness #primarycare pits GFR vs proteinuria in CKD

In this tweetorial let's take a closer look at GFR

But first, who has your vote?#NephTwitter 2/ The concept of GFR as a marker of kidney function dates way back to the 1950s. (Apologies to the tubules, we do❤️you!)

But how could we measure GFR??

It was suggested that if a solute had certain characteristics its plasma clearance would = GFR

Let's briefly recap🤓

1/
Is a GFR of zero always = to kidney failure?
How important are glomeruli?
Are we secretly guilty of ignoring the humble tubule?
Let's have a look at the Seahorse, this year's contender for @NephMadness an AGLOMERULAR fish.
#AnimalHouse #NephTwitter @NSMCinternship @AJKDblog 2/
How can an aglomerular kidney provide the function of the kidney?
Let's briefly recap the function of the glomerulus and the tubule using what we know of human physiology