#Tweetorial1️
✅Only ~40-60% of GEA pts receive 2L Rx in the USA, & the treatment landscape is fragmented.
📌 pubmed.ncbi.nlm.nih.gov/25792290/
📌pubmed.ncbi.nlm.nih.gov/31056940/
@TumorBoardTues #TumorBoardTuesday #Tweetorial2
✅The Phase III 2L RAINBOW study of paclitaxel-Ram vs Paclitaxel had improved OS, serving as a benchmark SOC
📌thelancet.com/journals/lanon…

#TumorBoardTuesday
1/3 CASE: 35 y/o F w stage 4 (diffuse supraclav/RP M1 LNs) GEJ AC, HER2 IHC3+, PD on 1L FOLFOX-trastuzumab after ~12m w new lung&peritoneal dz. Repeat EGD w bx: HER2 IHC3+/CPS 0. ctDNA profile NO HER2 amp (TP53 mt MAF 9.3%).
How would u treat this pt now?

https://twitter.com/tumorboardtues/status/1358755663493660672

#TumorBoardTuesday
2/3 CASE:35 y/o F w stage 4 (diffuse supraclav/RP M1 LNs) GEJ AC, HER2 IHC3+, PD on 1L FOLFOX-trastuzumab after ~12m w new lung&peritoneal dz. Repeat EGD w bx: HER2 IHC3+/CPS 0. ctDNA PROFILE w/o HER2 amp (TP53 mt MAF 9.3%). PS0
How would u treat this pt now?

Ok...Honeymoon is over & now time to dissect the exciting new data presented @ #ESMO2020 for #GEC #KN590 #CM649 #ATTRCN4 #CM577
1st, thank you to all the pts who participated!
& 2nd, congrats to all the investigators involved!
It's fantastic to have +ve studies! Lets dive deep: *Caution
I think the facts are accurate - please correct if not. (seeking the truth here)
My opinions are my opinions.
~15 min read (it's complicated)
No CME offered unfortunately 😒😉
Enjoy...

Leading up to ESMO, would luv to hear predominant reason(s) why folks think CM649 is +ve but KN062 is -ve. Other ideas welcome! (Eg random chance that CM649 was +, or Kn062 missed a massive benefit by chance that now CM649 has uncovered!) @marklewismd @Labrat3 @NataliyaUboha @OncLive @OncoAlert @rutikamehtaMD @DrR_DUNNE @rcarvalhoonco @RussellPetty19 @rachnatshroff @RenoHemonc @KlempnerSam @Thalcin @TargetedOnc @mgibson21212 @practiceupdate @benweinbergmd @BenWestphalen @SteveMaronMD @mdmanishshah @SyedMAhmedMDPhD

It will be important to look at the data closely, particularly by histology. Merck’s KEYTRUDA® (pembrolizumab) in Combination W Chemo Significantly Improved OS and PFS Compared W Chemo in 1L Metastatic Esophageal Cancer | Business Wire businesswire.com/news/home/2020… We must recall that a ~500 pt study of the exact same regimen KN062 was recently statistically negative (HR0.85 p=0.046) in CPS>0 in adeno. Now the same regimen in KN590 N=749, in all-comers irrespective of PDL1 but including SCC, is +ve. What could be driving this difference?🤔

So great that HER2+ GEA has many promising new tx’s! The next yrs will be important for us to study how to optimally sequence of all of them to best treat our pts!!
#margetuximab #tras #tucatinib #trasderux #zw25 etc...

#retifanlimab #pembro #nivo etc...

thelancet.com/journals/lanon… In addition to the main text, be sure to check out pages 4-11 of the supplement. Lots of good stuff buried there. Most important to me are the biomarker subgroups analyses: “Targeted therapies for targeted populations!” Some long-term survival noted in the double-positive group.

🎶you may say I’m a dreamer...🎶 Overcoming Heterogeneity to Develop Targeted Therapies for Gastroesophageal Cancer prac.co/l/ybw6j8e6 via @practiceupdate @LizzySmyth1 PANGEA2 planning with @KlempnerSam !!

What is your risk of dying from coronavirus? worldometers.info/coronavirus/co… What is your risk of dying from coronavirus? worldometers.info/coronavirus/co…

One of my labors of love. Appropriately online on Valentine’s Day! ❤️ Perioperative gFOLFIRINOX for #GEA with premptive iri dose reduction of hi risk UGT1A1 genotypes. ja.ma/2vCgd7T @UCCancerCenter @kturaga @SteveMaronMD with nice commentary @JoeChaoMD & @KlempnerSam. @UChicagoMed @UChicagoNews @JAMANetworkOpen #gFOLFIRINOX

Surprise surprise. The group that benefits from 1L pembro is largely driven by MSI-high tumors. This should have been included in the original #ASCO2019 presentation. 😡 #KN062 #ESMO2019

FIGHT-202 anti-FGFR2 pemigatinib for FGFR2 fusion cholangiocarcinoma. Very impressive 3-arm non-randomized phase 2