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Michael D. Shapiro Profile picture
Michael D. Shapiro
@DrMichaelShapir
prevention of cv disease @wakehealth
Sep 20 • 7 tweets • 1 min read
Really nice paper looking at mechanism of LDL-C increase with SGLT2i. A tweetorial @ASPCardio



1/ahajournals.org/doi/epdf/10.11… Under normal conditions, SGLT2 in the kidneys reabsorbs glucose. SGLT2i inhibit this process, leading to glucose excretion & lower blood glucose. But they also alter lipid metabolism, especially increasing LDL @nationallipid

2/
May 19, 2023 • 8 tweets • 5 min read
Cholesterol-Years: Why Starting LDL-C Reducing Strategies Earlier Matters

Ever wondered why it's crucial to address LDL cholesterol levels early in life? In this tweetorial, we'll explore the concept of "cholesterol-years" and delve into the significance of starting LDL-C reducing strategies sooner rather than later. Let's dive in. #CholesterolYears #HeartHealth @ASPCardio @nationallipid