Philip Dunne Profile picture
Molecular Pathology Group Leader. Tumour-based transcriptional signalling and early dissemination in colorectal cancer. Deputy Chair NCRI Colorectal Group
Apr 16, 2022 20 tweets 10 min read
Do you use transcriptional signatures?

Do you assume they represent the same biology in pre-clinical & clinical samples?

What if I told you some of the most widely-used signatures in cancer research are being completely misinterpreted.… read on👇👇🧵 For a long time we have been using clinical samples to identify epithelial biology and signalling in specific cells of interest, but in the end we knew we needed to find a better way to account for the histological heterogeneity of diagnostic tissue samples