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Philip Dunne Profile picture
Philip Dunne
@DrPipDunne
Molecular Pathology Group Leader. Tumour-based transcriptional signalling and early dissemination in colorectal cancer. Deputy Chair NCRI Colorectal Group
Apr 16, 2022 • 20 tweets • 10 min read
Do you use transcriptional signatures?

Do you assume they represent the same biology in pre-clinical & clinical samples?

What if I told you some of the most widely-used signatures in cancer research are being completely misinterpreted. biorxiv.org/cgi/content/sh… read on👇👇🧵 For a long time we have been using clinical samples to identify epithelial biology and signalling in specific cells of interest, but in the end we knew we needed to find a better way to account for the histological heterogeneity of diagnostic tissue samples