🔟clinical clues in diabetes care🧵

1⃣Classification (evolving): type 1, type 2 (90%), gestational, other (meds, genetics, endocrinopathies etc)
2⃣Type 1 and 2 can occur in any age group
3⃣1/3rd of children with type 1 present with DKA

1/7 4⃣Three stages of type 1 diabetes

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Carney triad vs. Carney dyad 🧬 #endotips (thread👇)

A diagnosis of Carney triad requires co-existing paraganglioma (PGL), pulmonary chondroma, and gastrointestinal stromal tumor (GIST) with either a germline pathogenic variant in SDHx or SDHC locus-specific hypermethylation In contrast, Carney dyad is the association of PGL and GIST with a germline pathogenic variant in SDHx. Don't confuse them with Carney complex, an autosomal dominant lentiginosis syndrome with myxomas, endocrine tumors or overactivity, and schwannomas👇

#endocation #endorules #endotips #endotwitter

🫀Molecular mechanisms involved in the different types of monogenic hypertension (thread)👇 🔹Gordon syndrome
▪️Autosomal dominant: WNK1 (GoF), WNK4 (LoF)
▪️AKA Pseudohypoaldosteronism Type II
▪️⬇️renin, normal/⬆️aldosterone (mimicking biochemically mild primary aldosteronism), BUT hyperkalemia
▪️Metabolic acidosis, hypercalciuria,⬇️UNa
▪️Rx: low dose thiazide