Did you know some of the oldest humans to ever live were smokers? 🚬

Some even credited their extraordinary longevity to smoking cigarettes

Is there an unknown mechanism by which nicotine could promote longevity in a select few?

🧵 To be clear: I do not advocate smoking.

I am merely interested in the potential benefits of exogenous nicotine

🚨 The most important organ you know nothing about:

➡️The Extracellular Matrix

This hidden network of proteins and connective tissue governs cell detoxification, nutrient transport, and cellular bioenergetics.

Here's what you need to know👇 1/ What is the ECM?

It is a dynamic structure of proteins (collagen, elastin), glycoproteins and glycosaminoglycans

Occupying the space between cells which spans the entire body, it provides structural support while acting as a dynamic signaling and biochemical regulator.

1/ Could a localized thiamine (vitamin B1) deficiency in the GUT be a root cause of common GI disorders?

Your intestinal cells might experience a deficit of B1 even when systemic levels are "normal."

We recently submitted a paper on this (in peer review)

A thread🧵👇 2/ How does this look in real life?

B1 deficiency symptoms may present solely in the gut:

🔹SIBO
🔹Low stomach acid
🔹GERD
🔹Leaky gut
🔹Gastroparesis
🔹Gut inflammation

All can be signs of a localized deficiency which doesn’t show up on tests or in other organ systems

My approach to fixing dysautonomia post-COVID/ mRNA shots🧵

Targeting the CHOLINERGIC system with 3 therapeutic agents

Autonomic nervous system dysfunction is extremely common in this cohort - especially after mRNA.

4 years on - A lot of people are still sick, and dysautonomia can can account for many (if not all) of the symptoms Spike protein binds nicotinic acetylcholine receptors and triggers degeneration of cholinergic neurons

Spike also impairs the production of acetylcholine in said neurons.

Without acetycholine, the nervous system begins to malfunction

A hidden deficiency of thiamine (vitamin B1) is one of the most common causes of:

- Acid reflux
- Functional dyspepsia
- Gastroparesis
- SIBO & IBS
- Constipation
- Intestinal permeability

Yet you won't read this in any textbook & practically no one knows. Here's how it works: 2) For healthy digestion, your digestive organs need to know what to do and at what times.

They receive this information directly from the BRAIN via autonomic nervous system

When your gut doesn't receive the right messages at the right times, you can develop signs of poor digestion

Most gut issues are a symptom of an underlying defect in either 1. secretion or 2. motility/muscular control

Your gut needs receive the correct top-down signals from the brain to successfully:

- Secrete stomach acid, chyme, digestive enzymes

- Control when sphincters open and close

- Contract smooth muscles of the stomach and intestine to propel food through the GI tract at a normal rate

The Ultimate Thread on Nicotine 💪

A pro-metabolic, anti-inflammatory, performance-enhancing, dopaminergic, neuroprotective POWERHOUSE

Learn how this unique substance supercharges the brain:

- Improve focus, cognition & memory recall
- Maximize learning & productivity

#Therapueticnicotine You'll also learn how nicotine can be protective against a variety of health conditions including:

- Parkinson's disease
- Dementia
- Inflammatory bowel diseases
- Depression
- Schizophrenia
- COVID/mortality due to other viral infection

#Therapeuticnicotine

Mechanism behind thiamine's unique ability to reverse disease (even without a deficiency):

- Oxidative stress, inflammation, and toxins inactivate our cell machinery used to generate energy

- Sustained mega doses of B1 can re-activate these enzymes, restoring energy & function The thiamine-dependent enzyme a-KGDH is extremely sensitive to oxidative stress and toxicity.

This is a RATE-LIMITING enzyme. When it becomes inactivated, mitochondrial energy metabolism shuts down.

This enzyme is decreased in a variety of neuro-degenerative conditions

Here are 5 nutritional supplements which can be effective for benzo withdrawal.

At the cellular level, withdrawal appears to involve:
- Structural changes in the GABA-a receptor
- Loss of sensitivity to GABA
- Rebound glutamate excitoxicity

Explanation in following tweets... 1) Agmatine is a metabolite of arginine which modulates NMDA receptor function.

A recent study on benzo withdrawal demonstrated:

-Significant reduction in symptom scores
- Increased GABA
- Lower glutamate
- Major improvement across the board

#benzo withdrawal

SIBO, IBS, GERD, and gastroparesis are usually treated with a 'bottom-up' approach - focusing on gut bacteria as the culprits.

But when the antibiotics/probiotics fail to work after multiple rounds, it is time to take a "top down" approach - read on...

eonutrition.co.uk/post/when-sibo… The autonomic nervous system is the PRIMARY controller of all digestive functions:

- Stomach acid secretion
- Pancreatic enzyme secretion
- Stomach and intestinal motility
- Intestinal barrier and mucosal integrity
- Modulation of intestinal inflammation

Here is how it works: