A hidden deficiency of thiamine (vitamin B1) is one of the most common causes of:

- Acid reflux
- Functional dyspepsia
- Gastroparesis
- SIBO & IBS
- Constipation
- Intestinal permeability

Yet you won't read this in any textbook & practically no one knows. Here's how it works: 2) For healthy digestion, your digestive organs need to know what to do and at what times.

They receive this information directly from the BRAIN via autonomic nervous system

When your gut doesn't receive the right messages at the right times, you can develop signs of poor digestion

Most gut issues are a symptom of an underlying defect in either 1. secretion or 2. motility/muscular control

Your gut needs receive the correct top-down signals from the brain to successfully:

- Secrete stomach acid, chyme, digestive enzymes

- Control when sphincters open and close

- Contract smooth muscles of the stomach and intestine to propel food through the GI tract at a normal rate

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Mechanism behind thiamine's unique ability to reverse disease (even without a deficiency):

- Oxidative stress, inflammation, and toxins inactivate our cell machinery used to generate energy

- Sustained mega doses of B1 can re-activate these enzymes, restoring energy & function The thiamine-dependent enzyme a-KGDH is extremely sensitive to oxidative stress and toxicity.

This is a RATE-LIMITING enzyme. When it becomes inactivated, mitochondrial energy metabolism shuts down.

This enzyme is decreased in a variety of neuro-degenerative conditions

Here are 5 nutritional supplements which can be effective for benzo withdrawal.

At the cellular level, withdrawal appears to involve:
- Structural changes in the GABA-a receptor
- Loss of sensitivity to GABA
- Rebound glutamate excitoxicity

Explanation in following tweets... 1) Agmatine is a metabolite of arginine which modulates NMDA receptor function.

A recent study on benzo withdrawal demonstrated:

-Significant reduction in symptom scores
- Increased GABA
- Lower glutamate
- Major improvement across the board

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SIBO, IBS, GERD, and gastroparesis are usually treated with a 'bottom-up' approach - focusing on gut bacteria as the culprits.

But when the antibiotics/probiotics fail to work after multiple rounds, it is time to take a "top down" approach - read on...

eonutrition.co.uk/post/when-sibo… The autonomic nervous system is the PRIMARY controller of all digestive functions:

- Stomach acid secretion
- Pancreatic enzyme secretion
- Stomach and intestinal motility
- Intestinal barrier and mucosal integrity
- Modulation of intestinal inflammation

Here is how it works: