PLA2R facts
✅Present in healthy human podocytes
✅70-80% 👥with 1ry MN & ~ 60% of ALL MN
✅Serum Ab are measured via ELISA & IF
💡💡DX:
🧪ELISA > 14 RU/mL or
🧪ELISA 2 - 14 RU/mL WITH a positive IFA pubmed.ncbi.nlm.nih.gov/34556256/
Oct 31, 2021 • 19 tweets • 9 min read
1/ 🚨Is sodium bicarbonate useful to prevent Rhabdomyolysis induced AKI ❓❓🚨
We get asked this all the time! But in order to understand it, let's start with a simple question
What is the mechanism of AKI in rhabdomyolysis ❓❓
2/ 1⃣What happens in rhabdo?
⚡️Muscle necrosis → release of intracellular components (enzymes-CK, electrolytes & myoglobin)
⚡️Fluid sequestration within damaged muscle → volume depletion →🚨 RAAS➕SNS
⚡️Oxidative injury →⬆️ in vascular mediators → ⬇️renal blood flow
