First tweetorial of the new academic year. Coagulase negative Staphylococci (CoNS) bacteremia is a frequent ID consult. So how do the pros handle the CoNS? Here is a quick generalized approach I use by creating a mnemonic out of CoNS. 1/10 First, remember that coagulase is a test which is used to differentiate coagulase negative Staphylococci from S. aureus, which is coagulase positive and always a pathogen. Image from microbiologyinfo.com. 2/10