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Edouard L. Fu Profile picture
Edouard L. Fu
@FuEdouard
Postdoc @BrighamWomens & @harvardmed Editor @NDTsocial My research: cardiorenal epidemiology, pharmacoepi, causal inference, trial emulation
Dec 1, 2021 • 19 tweets • 7 min read
Why did observational studies find ⬆️survival for late dialysis initiation, whereas the IDEAL RCT found no difference? Was it confounding, the usual culprit we point to? No!

Our new paper @bmj_latest addresses this and much more! #epitwitter #nephtwitter
bmj.com/content/375/bm… By carefully reading the previous observational studies (refs 14-32 in our paper), we identified that virtually all of them suffered from study design errors

This introduced 3 preventable biases, ON TOP OF confounding
1⃣ lead time bias
2⃣ immortal time bias
3⃣ survivor bias
2/n