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Intensivist I Internal Medicine | ☕️, 🍩, 🥐, 🍫 addict
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Sep 12 20 tweets 6 min read
ICU/ED/OR #Hemodynamics:

IKYK that: i) blood pressure (BP) is the driving force for organ perfusion, but ii) hypotension does not always lead to hypoperfusion

One of my favorite reviews (PMID: 34392972) tries to reconcile the paradox and expand on the topic: Image Fact:

Although an abundance of cohort studies have suggested an association between hypotension & unfavorable outcomes, several RCTs have failed to demonstrate consistently improved outcomes from maintaining a higher BP
Sep 2 12 tweets 3 min read
ICU Practice - Return to Basics:

When you prepare for the "average" intubation (no cardiac arrest, no active emesis), how do you pre-oxygenate the patient? In PREOXI, a multicenter, randomized trial conducted in 24 🇺🇸 EDs and ICUs and published in 2024 (PMID: 38869091), 1,301 critically ill adults were randomly assigned to receive preoxygenation with either noninvasive ventilation (NIV) or an oxygen mask (O2M) Image
Image
Aug 30 11 tweets 2 min read
ICU Practice - Return to Basics:

For the average RSI - rapid sequence intubation (no cardiac arrest, no active emesis), do you provide bag-mask ventilation between induction and laryngoscopy (I & L)? RSI flow(s): Image
Image
Aug 27 4 tweets 1 min read
Decongestion Secrets ("ammo" for rounds):

In a multicenter study of 283 acute heart failure patients, changes in renal filtration markers (cystatin C or creatinine) with aggressive diuresis were not associated with changes in markers of renal tubular injury (NAG, NGAL, or KIM-1) Image In this aggressively diuresed population (560 mg iv furosemide -> urine output of 8425 mL over 72h), both worsening renal function & increases in tubular injury biomarkers were not associated with adverse outcomes; rather, there was a trend towards improved outcomes Image
Aug 24 14 tweets 2 min read
Ten things that -for no good reason- we don't do in the ICU:

OK, in general a "less is more" approach is reasonable & there is a "rationale" behind many of the following but the truth is that they don't make sense if scrutinized

Here it begins:

1. Holding tube feeds or any type of nutrition, because the glucose is "high"...

I see it often when I do morning rounds; the tube feeds were held at 2:00 am (and never restarted) because glucose was 400. Obviously, the right approach is to adjust the insulin regimen and keep feeding the patient.
Aug 23 10 tweets 2 min read
ICU ID Secrets:

77 yo patient admitted to the ICU from a nursing home w hyperglycemic-hyperosmotic state & acute kidney injury. On day 6, he spikes a temp 38.3. BP 96/59, HR 110/min. UA suggestive of urinary tract infection. The next day, urine culture grows Enterobacter cloacae Image A day later, the blood culture grows Gram (-) rods (eventually proven to be the same bug). The susceptibility profile is: Image
Aug 17 19 tweets 3 min read
(Basic) ICU Hemodynamic “Secrets” - Part2:

I know you know them, but let’s remind ourselves of some additional basic hemodynamic "secrets": Image 16. Volume status is a nebulous term, but I don’t foresee stop using it anytime soon
Aug 16 19 tweets 3 min read
(Basic) ICU Hemodynamic “Secrets” - Part1:

I know you know them, but let’s remind ourselves of some basic hemodynamic "secrets": 1. Pressure ≠ volume, even though volume can affect pressure
Jul 31 9 tweets 2 min read
ICU Snapshots:

Elderly 👴 w interstitial🫁disease was admitted -on NIV- from the ED to StepDown unit w "pneumonia": bil infiltrates/low-grade fever. PF ratio 140. Since I was in the ICU, I asked how he looked. Reply: needs high FiO2 but pulls good tidal volumes

When I saw him: Image This is not an uncommon scenario: a "low" expired tidal volumes (Vt) makes the staff worried during NIV initiated for hypoxemic respiratory failure but a "high" Vt (even if accurately measured) is left unabated...
Jul 21 15 tweets 3 min read
The American Thoracic Society (ATS) updated its recommendations on some aspects of the diagnosis and management of community-acquired pneumonia (CAP) Image This guideline update focuses only on immunocompetent adult patients with a standard diagnosis of CAP

It addresses four clinically relevant questions: Image
May 17 14 tweets 3 min read
ICU/ED Pharmacology/ID Secrets:

Have you ever managed a septic patient & ordered antibiotics to be given stat only to discover hours later that they were still infusing? If yes, stay tuned

Among several controversies in sepsis management, the early administration of antibiotics Image
Image
is one of the least debatable ones. Time is life in sepsis!

Even though it's hard to believe that every hr of delay in antibiotics ⬆️ mortality by 8% (this is a different topic...), it's one of my pet peeves when it takes for ever to give antibiotics to a septic shock patient
May 3 21 tweets 4 min read
ICU Upper GI Bleeding (UGIB) Secrets:

Is there anything regarding UGIB that has not been already done, studied or tweeted about? Not much, but all of the following are things I witnessed happening (or not happening…) in two UGIB cases I recently saw in the ICU

Here it begins: 1. If a patient does not have an obvious UGIB as in the clip above, she has just presented with melena & it is still unclear if this is due to upper or lower GIB, a quick & dirty trick is to check the blood urea nitrogen/creatinine (BUN/creat) ratio. There are various published
Apr 28 5 tweets 2 min read
The patient whose ECG/POCUS clips I posted yesterday has remained hemodynamically stable & neurologically intact

This was the #ECG today; still looking angry: Image I repeated #POCUS; no significant changes:
Apr 27 11 tweets 3 min read
ICU Stories:

Walking from room to room in the ICU on a Sunday morning while hoping to have a quiet shift, you notice this 👇 on a patient's monitor (60 yo, admitted, intubated for COPD exacerbation + pneumonia 3 days ago, now sedated/hemodynamically stable) Image It's unfortunately hard to pretend you didn't see it, so you get an ECG praying that it will not show what you saw on the monitor... 😊

Of note, admission ECG was "ok"

Well, it actually looks more impressive on the 12-lead ECG: Image
Apr 26 22 tweets 5 min read
ICU Line Secrets:

Is there anything about "lines" that has not been done or studied already? Not much, I guess, so these actually are not secrets, just things I had to do the last couple of weeks & hopefully you also find useful in your practice

Here it begins:

1. "Twin lines" Image in the same vessel, if there is anatomical reason/venous thrombosis etc that limits the available options. I have even placed a 3rd line (Swan sheath) in the RIJ at the same time but the more of venous real estate is occupied by catheter lumens,
Apr 10 10 tweets 3 min read
Refresher on Swan-Ganz catheter: Image Comparison of pulmonary artery catheterisation with different cardiac output monitoring devices: Image
Apr 6 7 tweets 2 min read
ICU Hemodynamics:

If you are managing patients with #vasoplegicshock, this is a nice review article: Image Vasoplegic shock (VS) is common, contributing up to two-thirds of cases of shock admitted to the ICU

The two most common VS causes: septic shock & vasoplegic shock after cardiopulmonary bypass

There is NO consensus definition of vasoplegic shock
Mar 22 26 tweets 6 min read
ICU Stories:

Elderly patient with multiple medical problems (HFpEF / A fib / HTN / PE / obesity etc) was admitted w CHF exacerbation. Improved w diuresis but developed left upper extremity edema; diagnosed with extensive DVT for which Interventional Radiology (IR) was consulted Image
Image
IR found severe L subclavian stenosis at the intersection of the clavicle & 2nd rib & upstream LUE extensive DVT. Performed successful image-guided LUE DVT mechanical thrombectomy & stenotic site angioplasty with near complete resolution of clot burden & improvement of stenosis
Mar 20 4 tweets 1 min read
ICU Hemodynamics:

Assessment of the efficacy (stroke volume) and tolerance (left ventricular filling pressures) of blood volume expansion using Doppler echocardiography: Image The 1st fluid challenge resulted in a large ⬆️ in LV stroke volume (38 to 65 mL), whereas the 2nd was unsuccessful (65 to 69 mL). The mitral Doppler profile progressed from “abnormal relaxation” to “restriction to filling” consistent with a gradual ⬆️ in left cardiac pressures
Mar 16 18 tweets 3 min read
ICU Hemodynamic Secrets – The role of ScvO2:

There is not such a thing as a “normal” cardiac output (CO). A CO of 3.5 l/min may be adequate for a 90 years’ old, 100 pounds sedated patient but inadequate for a 40 years’ old, 250 pounds patient with septic ARDS. Ideally, any CO value should be accompanied by an assessment of the adequacy of perfusion (clinical: mental status, urine output etc or laboratory: central venous O2 saturation, lactate etc)
Mar 16 34 tweets 8 min read
ICU #POCUS:

This is a recently published, information-dense document. It may be a bit technical for the average POCUS user but if you manage patients who harbor a right heart, consider reading it: Image It is a 40+ pages' document, so I will just highlight some of the most useful points: Image