Happy to share my third PhD paper, published at @ACSSynBio! We developed a recombinase-based system to transfer large biosynthetic gene clusters into filamentous fungi heterologous hosts for #naturalproduct discovery. @YitHengChooi @SMS_UWA #Synbio (1/8)
doi.org/10.1021/acssyn… We often find promising cryptic biosynthetic gene clusters (BGCs) in the genomes of fungal species that are hard to cultivate or genetically intractable. Heterologous expression in hosts such as Aspergillus nidulans is increasingly being used to access the encoded compounds.(2/8)