New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵 2/ This study was led by Charlie Moffatt, who just earned their PhD from our lab based in part on this work. @CUAnschutz ⭐️ Preprint here: biorxiv.org/content/10.648…

Excited to share our newest manuscript! We find that RNA localization mechanisms that send RNAs to a given subcellular structure in one cell type can *predictably* traffic RNAs in other cell types, even if they don't have that subcellular structure. biorxiv.org/content/10.110… In short, we define subcellular spatial equivalents, at least as far as RNA localization is concerned, across cell types with very different morphologies.

This is primarily the work of @RnaRae with help from @arorankita.

Excited to share our latest manuscript! How does an RNA get transported in neuronal cells? What sequences within the RNA govern this? We used a massively parallel reporter assay to identify sequences necessary and sufficient for RNA localization. 🧵biorxiv.org/content/10.110… This work was led by the very talented @arorankita in collaboration with @russ_holger @RobertoCG96 and @AndreasMoor. It's part of a trio of complementary manuscripts from @chekulae @IgorUlitsky @AndreasMoor @martinjmikl that explore this question!