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Jase Gehring Profile picture
Jase Gehring
@JaseGehring
Developing advanced molecular technologies at @arcadiascience. Genes, Genomes, Genomics, and Multiplexing. The possibilities are endless… he/him
Sep 12, 2020 • 24 tweets • 4 min read
This is a thread on ENDING TEMPORARY POSITIONS IN UNIVERSITY RESEARCH.

I wrote this in response to some comments. I’m fleshing out my thoughts and shaping my opinions. I share to provoke discussion and introspection. It's ~500 words. First, it is entirely rational to compete within the current system based on your CV. I recognize this is how I will be judged, and I act accordingly. I don't blame others for doing the same. But, “you get what you select for”; so, are we selecting for CV builders or scientists?
Aug 30, 2020 • 7 tweets • 2 min read
the most successful grad students have tons of experience *before* starting their PhDs. Essentially, they don't need to be trained, and they flourish in a system that explicitly avoids directly training them. background:

- went from undergrad after 1.5 yrs great training
- trained mostly by grad students during rotations
- switched labs after 4 yrs (to a way better situation!)
- probably would not have been successful as a grad student in my current postdoc lab
Jul 17, 2020 • 8 tweets • 1 min read
as a biologist who is usually not suuper interested in human health projects and very not interested in rodents, i default to telling those who are that i am a chemist.

it's so much easier than trying to explain my views. ooofff this is turning into a thread.
Jun 21, 2020 • 5 tweets • 1 min read
great thread! so how we doing? imo personal testing is nearing sufficiency nationwide. that's the 'anyone who wants a test' crowd.

a bigger question is if testing will be *asked* of people who aren't sick. this remains very limited at this time. still controversial some prevalence studies exist, like SCAN in Seattle, and some mitigation testing is being done like at Amazon, sports leagues, and certain major transmission chains. 2/4
Jun 13, 2020 • 4 tweets • 1 min read
this error is subtle to non-experts, but it is Day 1 qPCR stuff, and a second major blunder in the CDC SARS-CoV-2 assay after the contaminated standards.

@cdc can issue new DNA sequence design recommendations - will they?

incredible quote below "It is somewhat puzzling that a primer/probe set that is frequently used to determine copy number variation in the human genome ended up as a control for RNA extraction and/or RT efficacy, since it is clear from the design that background gDNA will pose a major problem."

WOW 😮
Jun 9, 2020 • 5 tweets • 1 min read
This is pathetic. If you were pissed at Angewandte before, this excuse gives you zero reason to submit your articles to this journal. There is no institutional accountability and no self-awareness. Most importantly, there are no steps to prevent further incidents. In short, you have no reason to believe that Angewandte is not just as discriminatory as their recent article except 1) Dave's words 2) they don't like that guy Hudlicky now, and 3) a couple editors are on leave (but they weren't racist anyway so nbd)
Jun 6, 2020 • 6 tweets • 2 min read
Just reading a @biorxivpreprint that's a real outlier in quality. Looks like an undergrad report, claims not supported by data, author lists don't match... it's rough.

Is there a mechanism to report borderline work? I'm not in a position to make the call, and "I don't think this is good enough" isn't the kind of public commentary i want to see/create. But this one maybe shouldn't have passed screening.

Surely more egregious submissions are retracted when necessary?
Jun 4, 2020 • 4 tweets • 1 min read
i think i speak for lots of scientists when I say we're terrified and we don't know what's going to happen with the ongoing outbreak. it's basically fingers crossed that masks/outdoors/behaviors limit spread, but we will see. very volatile situation. The stage is now set for much greater unrest in the US. THIS is why an effective pandemic response was so important. The virus is not gone and there is potential for the outbreak and its consequences to grow much more severe.
Jun 3, 2020 • 10 tweets • 3 min read
Sioux City: FINALLY voted out racist representative
Omaha: Black protestor KILLED by racist, NO CHARGES
Chapel Hill: please, the bigotry is well established
Pasadena: Truck with "blue lives matter" flag drives through crowd.
Seattle: police mace a child

yes. feeling this. 1/8 I also lived in Berkeley, the most welcoming place i've known, and I'm sure Seattle will respond boldly.

every other place has SERIOUS work to do, but axes of racial tension are different. 2/8
Feb 25, 2020 • 4 tweets • 1 min read
ok NOW we sequenced the human genome.

As an aside, maybe we can stop establishing nebulous research objectives like "sequence the human genome" and "catalog all human cell types" for the not-so-secret purpose of directing money to the right people. The human genome and cell atlas are not static, cannot be reasonably "completed" with current resources, and cataloging alone will not get us very far.

We need a shift in focus toward tech dev + parallel experimentation and less emphasis on large datasets.