1/ I promised an updated version of our Medrxiv paper so here it is! The title has changed because we have looked at 2 cohorts of fully vaccinated participants who experienced breakthrough infections.
medrxiv.org/content/10.110… 2/ Some take-aways: (a) 1 dose of mRNA vaccination elicits a modest sIgA response to Spike in the saliva of almost all healthy participants. (b) Only 30% of participants maintain their sIgA response to Spike after dose 2 whereas anti-Spike IgG in the saliva is boosted by dose 2.

1/ Big weekend for those of us thinking about eliciting mucosal immunity for protection against SARS-CoV-2. New studies by @florian_krammer, @VirusesImmunity and @McMasterU herein as well as an update on our own work. 2/ First a new study posted by @florian_krammer on salivary Ab titres post 2x mRNA vaccinated, comparing with previously infected and subsequently vaccinated.

1/ I’m super excited to post our recent findings on the mucosal immune response to COVID-19 vaccines. medrxiv.org/content/10.110… 2/ In this manuscript, we show that the IgG anti-Spike response in the saliva to mRNA/mRNA and Ad/mRNA vaccination regimes reflects the serum IgG response. However, we also observe a saliva IgA response that is associated with secretory component, particularly after one dose.