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Jenny Seligmann Profile picture
Jenny Seligmann
@JenSeligmann
Optimist. Prof GI medical oncology. Coffee, Irn-Bru & dog enthusiast @foxtrotstudy @focus4trial @ArielTrial #pelotonuk 🇪🇺
Jan 20, 2023 • 15 tweets • 11 min read
🥁🥁🥁Tweetorial
FOxTROT, the 1st ph 3 RCT of neoadjuvant chemo (NAC) in locally advanced colon cancer
We report that NAC is
✅deliverable and safe
✅led to statistically significant reduction in cancer recurrence than upfront surgery
A 🧵 (1/14)
#crcsm
ascopubs.org/doi/full/10.12… 2/14 The trial:
⭕️moved 6 weeks of chemo ahead of surgery, vs standard treatment.
⭕️Same total duration of chemo in each arm (pre-IDEA so total duration 24 weeks)
⭕️ primary endpoint 2 year RFS
1053 pts from 85 centres in 3 countries Image