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John Beach Profile picture
John Beach
@JohnBeachTX
Technology sales & consulting. Demonstrated insights in medical diagnostics, biochemistry, & use to assess/treat/cure health threats like COVID-19 / SARS-CoV-2
Feb 20, 2023 • 6 tweets • 5 min read
@BrownJHM @AaronGoodman33 The Brown Recluse.
As replies note, its bite injects a potent hydrolase enzyme:
Sphingomyelinase D,
a sphingomyelin phosphodiesterase, which breaks sphingomyelin into phosphocholine & ceramide.

Treatment? Wikipedia options sound inadequate.

PubMed inspired many questions!

1/n @BrownJHM @AaronGoodman33 In PubMed, this caught my eye:
pubmed.ncbi.nlm.nih.gov/25938271/
Sphingomyelinase D/ceramide 1-phosphate in cell survival and inflammation

the venom of Loxosceles, or the toxins of some bacteria such as
Corynebacterium tuberculosis, or
Vibrio damsela
possess high levels of SMase D

2/n
Feb 18, 2023 • 16 tweets • 14 min read
Due to cats' enzyme activity, cats don’t make niacin, & I infer this makes cats resistant to infection by tuberculosis.

I asked ChatGPT:
What other bacteria utilize niacin for growth, reproduction or virulence? Of these bacteria, which cause disease in humans, not in cats?
1/n Partially unverified ChatGPT answer, edited:

Other bacteria that utilize niacin include
Staphylococcus aureus,
Salmonella,
Vibrio cholerae,
Listeria monocytogenes,
[which] cause disease in humans but not in cats.

I skimmed much research, as I checked the ChatGPT answer.

2/n Image
Feb 15, 2023 • 6 tweets • 7 min read
@BrownJHM @Radiopaedia Great tweet & replies re
patient w/ history of leukemia presented with fever & cough.
Replies : cryptoccocus neoformans

The case reminded me of another thread on pyruvate carboxylase & leukemia.


So I skimmed Google Scholar my own tweets and…

1/2 Image @BrownJHM @Radiopaedia Much to learn re
infection, leukemia, PC, etc.

Someday, I’ll retrace this exploration to where I saw
pubmed.ncbi.nlm.nih.gov/10792784/
apoptotic cell death in granulomatous inflammation induced by intravenous challenge with Cryptococcus neoformans and bacillus Calmette-Guérin vaccine

2/2 ImageImageImageImage
Mar 13, 2020 • 6 tweets • 4 min read
@anish_koka “Why are the elderly more affected?” seems both obvious/dumb & subtle/important.

How do their diagnostics compare to those less affected?
Growth factors, calcitriol, XO, Uric acid, IFN-gamma, IDO, status of kynurenic pathway, BDNF, mir-206, neopterin, lactate dehydrogenase @anish_koka Where is more data like this?