Very happy to distribute here the latest paper from the @IAEANA DLW database published in @NatMetabolism which concerns the decline in energy expenditure over the last 3-4 decades in the USA and Europe. 1/
nature.com/articles/s4225… Obesity is caused by an imbalance of expenditure and intake. There has been previous debate about the relative contributions falling expenditure due to declining physical activity, and increased food intake have made to the epidemic. 2/

Today is thanksgiving – and not coming from the US I am mostly giving thanks for our paper in Science published today on human water turnover. 1/
Variation in human water turnover associated with environmental and lifestyle factors | Science
10.1126/science.abm8668. The paper was led by Yosuke Yamada from Tokyo and used the IAEA DLW database to reconstruct the water turnover of over 5600 individuals. We found the main factors influencing WT are energy expenditure, body weight, physical activity, temperature, humidity, altitude and age. 2/

Our paper from the IAEA DLW database on effects of ambient temperature changes on human energy expenditure is now online at @iscience. Here is some background on the study, what we found and its implications. 1/16
sciencedirect.com/science/articl… Many scientists are looking at ways to switch on brown adipose tissue (BAT) to elevate energy expenditure and reduce obesity. But several studies showed BAT is activated in the cold. If switching on BAT combats obesity, the obesity prevalence should be less in colder areas. 2/16

Everyone has heard of people who are extremely lean and seem able to eat what they want because they burn it all off. We have now characterized the lifestyles and metabolism of underweight people @Cell_Metabolism
The results are unexpected
authors.elsevier.com/a/1fPf35WXUlP5…
1/n We recruited 150 people with BMI <18.5 living in Beijing, and compared them to 173 normal weight individuals (BMI 21.5 to 25). We screened out people with eating disorders, those living with HIV and individuals who had lost weight due to prior disease. 2/n

Live cold, die old? Our paper on the impacts of body temperature on lifespan is out today in nature metabolism. 1/n
nature.com/articles/s4225… An explainer of the main points. Live fast, die young, in biology refers to the observation that animals with high metabolic rates (living fast) tend to die sooner. the metabolic rate of a mouse is 30x faster than an elephant. It lives about 3 years and the elephant about 70. 2/n

Very happy to be part of another great paper using the IAEA DLW database (dlwdatabase.org). This time a forensic analysis of links between fat-free mass and physical activity led by Klaas Westerterp published in AJCN

pubmed.ncbi.nlm.nih.gov/34477824/

Main points as follows 1. Data comprised 2000 individuals aged 3 to 96 where total energy expenditure TEE and resting energy expenditure REE were available. Physical activity level (PAL) was calculated as the ratio of TEE/REE. Fat-free mass FFM estimated from isotope dilution.

Very happy to be part of this great paper led by @lewis_halsey and @CareauVincent using data from the DLW database (dlwdatabase.org) and published Open access in Current Biology

cell.com/current-biolog…

here are the main points 2. When we exercise we burn energy. However, those calories we burn do not necessarily translate into more calories burned at the end of the day. How is that possible if the laws of thermodynamics and energy conservation are correct?

I am wondering if anyone has thoughts on how and why a system as proposed in the carbohydrate-insulin model evolved? I mean why would we evolve a system that causes us to deposit fat when eating CHO? @davidludwigmd @garytaubes @eatlikeanimals @JimJohnsonSci @KevinH_PhD 1/5 I can understand why we might have a system that regulates calorie intake and expenditure (CICO) to regulate fat levels in relation to risks of predation and disease risk. 2/5
pubmed.ncbi.nlm.nih.gov/29514887/

Some comments on the latest interaction in @IntJObesity between @KevinH_PhD Juen Guo and myself and @davidludwigmd concerning the diet intervention study published late last year in @bmj_latest 1/n @IntJObesity @KevinH_PhD @davidludwigmd @bmj_latest A previous dispute focused on the choice of the reference point pre randomisation. Ludwig et al’s most recent IJO paper reiterates this debate showing that there is better correlation between their second chosen reference, rather than that originally registered.