Our follow-up study on IgG4 in blood and saliva after 4 x COVID-19 mRNA vaccines is out on eBioMedicine 🧪

1)🧵So how does IgG4 influence responses to Omicron (XBB.1.5 and JN.1) and Sarbecoviruses (from bats, pangolins)? What epitopes are being targeted?

authors.elsevier.com/sd/article/S23… 2) 🧵To begin, a quick recap that IgG antibodies switches from IgG3 >> IgG1 >> IgG2 >> IgG4

And that during chronic inflammation and allergies, IgG4 plays the important role of bringing balance back to the immune system