How does route of #mRNA #vaccination impact localization and abundance of CD8 & CD4 memory T cells? shorturl.at/foBMY

@TwiterlessBuck
@Masopust_Vezys

Thanks to all co-authors and sponsors including @Tibabiotech @niaidcivics @snsf_ch @CFI_UMN @rafiahmed_lab

🧵👇🏼 Take home:
✅intramuscular (IM) vaccination induces few lung TRM
✅intranasal (IN) vaccination makes more lung TRM
✅TFH memory is confined to vaccine-draining LN
✅IM prime+boost + IN boost establishes robust circulating and lung resident memory T cells