David Diamond Profile picture
Ph.D. in Biology/Neuroscience Professor, Univ So Florida My second career focuses on cardiovascular disease I'm skeptical of LDL cholesterol as a cause of CVD
3 subscribers
Apr 16 4 tweets 2 min read
This is a wonderful podcast with Dr. Vyvyane Loh:
@VyvyaneLohmd

She provides an evidence-based approach to heart disease. Everyone, especially cardiologists, can learn from her sophistication and scholarship.
@ethanjweissihmc.us/stemtalk/episo… @VyvyaneLohmd
It was such a pleasure to hear you cover the role of lipoproteins in immune function and the importance of a healthy glycocalyx in coronary artery functioning, two topics that are so important and yet not appreciated by cardio docs. Here is a slide from my talk (that I hope to share someday soon) at @realDaveFeldman 's Las Vegas meeting . Here I covered the importance of LDL in immune functioning.cosci.orgImage
Oct 2, 2022 15 tweets 9 min read
@JohnKastelein John - Perhaps the only thing we'll agree on is that FH ppl have high LDL and increased CHD early in life (as Mundal et al showed). Where we disagree is why this occurs. As FH ppl have high LDL all their lives, why does CVD mortality decline over time? @JohnKastelein While the increased CVD mortality early in life is frightening, the magnitude of the mortality overall is small, and all-cause mortality, even early in life, is not statistically significant compared to the non-FH population. So a small % of the FH population dies from CVD.
Jul 27, 2020 18 tweets 17 min read
1/18
Thnx @JTMarlin77 @janvyjidak for bringing @nutritiondanny & Alan’s podcast to my attention. The “ripping apart” of my paper is at ~1’15”
sigmanutrition.com/episode343/
Here’s my paper which was discussed:
ebm.bmj.com/content/early/… 2/18
D&A had a lot to say but didn’t actually read my paper. They saw #LCHF advocates in the au list & assumed (incorrectly) the paper advocated #LCHF for FH. They scoffed at my paper, co-written by 5 cardiologists, 2 au with PhDs in nutrition & all authors with an MD and/or PhD
Nov 22, 2019 15 tweets 36 min read
Day 2 Statin Adverse Effects:
Please RT to Dayspring & Peter Attia (Both block me)
Increased Brain Amyloid with Statins
dx.doi.org/10.1016/j.dadm…
@FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition @FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition Day 3 - Statin Adverse Effects:
Dose/Time Dependent Development of T2D
@lowcarbGP @DaveKeto @DavidPerlmutter
Jul 27, 2019 7 tweets 3 min read
Brian, Marion - IMO, you 2 are at extremes and I think of myself somewhere in between.
To Marion - Yes, there are reported harms of statins, no doubt, but if statins were a poison, as you consider it, the adverse effects would be more debilitating and more common. To Marion, as well, it appears to me that the majority of people have neither benefit nor adverse effects of statins. IMO, the physiology adapts to the statin-induced metabolic intrusion. and functions at a reasonable level.
Jul 19, 2019 6 tweets 3 min read
I didn't misrepresent your findings. I quoted your findings that statins didn't reduce sdLDL, which is consistent with other work showing that sdLDL doesn't bind to LDL-r and must be removed by macrophages, which is independent of statin mechanisms. I didn't say you consider statin effects to be weak - that's my interpretation of how your findings fit with the literature.
You, as well as @kevinnbass , would benefit from seeing the work of @KenSikaris who covers this topic so well:


@DrPaulMason also covers sdLDL beautifully.
Feb 17, 2019 11 tweets 5 min read
1) I don't know why I get linked to Koushik's tweets. I shouldn't engage him - he's a nice and sincere person, and has the best of intentions for his patients, but I prefer to connect with scientists and open-minded people, not a priest with daily WFPBD sermons. 2) What Koushik doesn't get is that the source of protein just doesn't matter. People can be healthy as vegetarians, which explains his good health and the good health of his disciples. People can also be healthy consuming meat of any kind, including steak.
Feb 6, 2019 13 tweets 7 min read
1) I admire MDs listed here because they recognize benefits of #LCHF diet. They question statin use for primary prevention, but each sees value of statins for 2nd CVD prev. My friendly challenge to them is in this tweet series.
@DrAseemMalhotra @bschermd @DoctorTro @FatEmperor 2) Let's start with the claim that 2nd prev benefits are substantial. The 4S study is often cited, but a 25 year old study with data analyzed by a "Merck employee" has little credibility. There's little after 2004 when standards go tougher; so lets go with the Brit HPS, from 2002