@JohnKastelein John - Perhaps the only thing we'll agree on is that FH ppl have high LDL and increased CHD early in life (as Mundal et al showed). Where we disagree is why this occurs. As FH ppl have high LDL all their lives, why does CVD mortality decline over time? @JohnKastelein While the increased CVD mortality early in life is frightening, the magnitude of the mortality overall is small, and all-cause mortality, even early in life, is not statistically significant compared to the non-FH population. So a small % of the FH population dies from CVD.

1/18
Thnx @JTMarlin77 @janvyjidak for bringing @nutritiondanny & Alan’s podcast to my attention. The “ripping apart” of my paper is at ~1’15”
sigmanutrition.com/episode343/
Here’s my paper which was discussed:
ebm.bmj.com/content/early/… 2/18
D&A had a lot to say but didn’t actually read my paper. They saw #LCHF advocates in the au list & assumed (incorrectly) the paper advocated #LCHF for FH. They scoffed at my paper, co-written by 5 cardiologists, 2 au with PhDs in nutrition & all authors with an MD and/or PhD

Day 2 Statin Adverse Effects:
Please RT to Dayspring & Peter Attia (Both block me)
Increased Brain Amyloid with Statins
dx.doi.org/10.1016/j.dadm…
@FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition @FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition Day 3 - Statin Adverse Effects:
Dose/Time Dependent Development of T2D
@lowcarbGP @DaveKeto @DavidPerlmutter

Brian, Marion - IMO, you 2 are at extremes and I think of myself somewhere in between.
To Marion - Yes, there are reported harms of statins, no doubt, but if statins were a poison, as you consider it, the adverse effects would be more debilitating and more common.

https://twitter.com/holmanm/status/1155148165185769472

To Marion, as well, it appears to me that the majority of people have neither benefit nor adverse effects of statins. IMO, the physiology adapts to the statin-induced metabolic intrusion. and functions at a reasonable level.

I didn't misrepresent your findings. I quoted your findings that statins didn't reduce sdLDL, which is consistent with other work showing that sdLDL doesn't bind to LDL-r and must be removed by macrophages, which is independent of statin mechanisms. I didn't say you consider

https://twitter.com/ckjellmo/status/1151983652378689542

statin effects to be weak - that's my interpretation of how your findings fit with the literature.
You, as well as @kevinnbass , would benefit from seeing the work of @KenSikaris who covers this topic so well:


@DrPaulMason also covers sdLDL beautifully.

1) I don't know why I get linked to Koushik's tweets. I shouldn't engage him - he's a nice and sincere person, and has the best of intentions for his patients, but I prefer to connect with scientists and open-minded people, not a priest with daily WFPBD sermons.

https://twitter.com/KoushikReddyMD/status/1097155270139088896

2) What Koushik doesn't get is that the source of protein just doesn't matter. People can be healthy as vegetarians, which explains his good health and the good health of his disciples. People can also be healthy consuming meat of any kind, including steak.

1) I admire MDs listed here because they recognize benefits of #LCHF diet. They question statin use for primary prevention, but each sees value of statins for 2nd CVD prev. My friendly challenge to them is in this tweet series.
@DrAseemMalhotra @bschermd @DoctorTro @FatEmperor 2) Let's start with the claim that 2nd prev benefits are substantial. The 4S study is often cited, but a 25 year old study with data analyzed by a "Merck employee" has little credibility. There's little after 2004 when standards go tougher; so lets go with the Brit HPS, from 2002