For #GIJournalClub – we will discussing the @NEJM article:
Atezolizumab + Bevacizumab in Unresectable HCC (IMbrave150 trial) by Dr. Richard Finn et al.
Expert opinion: @SeragHashem
Moderators: @AtoosaRabiee@jturnesv
Single agent PD-L1 inhibitor w/o improved OS
- Nivoumab vs sorafenib: No statistically significant improvement in OS w/nivolumab sciencedirect.com/science/articl…
Jun 25, 2020 • 15 tweets • 9 min read
For #GIJournalClub – we will discussing the @NEJM article:
Atezolizumab + Bevacizumab in Unresectable HCC (IMbrave150 trial) by Dr. Richard Finn et al.
Expert opinion: @SeragHashem
Moderators: @AtoosaRabiee@jturnesv
Single agent PD-L1 inhibitor w/o improved OS
✅ Nivoumab vs sorafenib: No statistically significant improvement in OS w/nivolumab sciencedirect.com/science/articl…
pubmed.ncbi.nlm.nih.gov/31895720/
⭐️ Coagulopthy of liver disease is a delicate balance ⚖️
☑️INR is 🚫 a useful marker to asses clotting & bleeding risk
☑️ For high risk procedures, consider TPO agonist if plt < 50k & not emergent (takes 5-7 days). beware in history of PVT
☑️Consider viscoelastic tests