For #GIJournalClub – we will discussing the @NEJM article:
Atezolizumab + Bevacizumab in Unresectable HCC (IMbrave150 trial) by Dr. Richard Finn et al.
Expert opinion: @SeragHashem
Moderators: @AtoosaRabiee @jturnesv

nejm.org/doi/full/10.10…

#livertwitter #GIJC #hpbcsm Background:
- Sorafenib in 2008: improved OS + longer time to radiologic progression vs placebo
nejm.org/doi/full/10.10…

Single agent PD-L1 inhibitor w/o improved OS
- Nivoumab vs sorafenib: No statistically significant improvement in OS w/nivolumab
sciencedirect.com/science/articl…

For #GIJournalClub – we will discussing the @NEJM article:
Atezolizumab + Bevacizumab in Unresectable HCC (IMbrave150 trial) by Dr. Richard Finn et al.
Expert opinion: @SeragHashem
Moderators: @AtoosaRabiee @jturnesv

nejm.org/doi/full/10.10…

#livertwitter #GIJC #hpbcsm Background:
✅ Sorafenib in 2008: improved OS + longer time to radiologic progression vs placebo
nejm.org/doi/full/10.10…

Single agent PD-L1 inhibitor w/o improved OS
✅ Nivoumab vs sorafenib: No statistically significant improvement in OS w/nivolumab
sciencedirect.com/science/articl…

Grateful to @DougSimonetto from @MayoClinicGIHep for talking to @UMN_GI about the recent the @AmCollegeGastro guidelines on Disorders of Hepatic and Mesenteric Circulation (as a part of our @AASLDtweets ELS project!)

pubmed.ncbi.nlm.nih.gov/31895720/ ⭐️ Coagulopthy of liver disease is a delicate balance ⚖️
☑️INR is 🚫 a useful marker to asses clotting & bleeding risk
☑️ For high risk procedures, consider TPO agonist if plt < 50k & not emergent (takes 5-7 days). beware in history of PVT
☑️Consider viscoelastic tests

@ScopingSundays @HassaanZiaMD @AtoosaRabiee @BilalMohammadMD @vaibhav_manu @AhmadBazarbashi @rmulkimd @RobertoSimonsMD @DrMalSimons @KellyHathornMD @NnekaUfereMD @JacquelineChuMD @TedWJamesMD 57 y/o M w/cirrhosis p/w melenic stools & hematemesis. EGD 1 yr ago w/small EV. BP 90/50, HR 110 & 96% on RA. Clammy extremities. Abdomen non tender. No ascites or edema. Pt has another episode of hematemesis. Hgb 8, Plt 165k, INR 1.8, Tb 2.1, Cr 1.4 & Na 134.
What is your plan? @ScopingSundays @HassaanZiaMD @AtoosaRabiee @BilalMohammadMD @vaibhav_manu @AhmadBazarbashi @rmulkimd @RobertoSimonsMD @DrMalSimons @KellyHathornMD @NnekaUfereMD @JacquelineChuMD @TedWJamesMD To start out #ScopingSundays - we will quickly review the pre-endoscopic management of bleeding esophageal varices!
#livertwitter #GITwitter #tweetorial