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Mia Petljak Profile picture
Mia Petljak
@MPetljak
@EMBOfellows Postoc @broadinstitute Golub/Regev labs | PhD @sangerinstitute | exFellow @VertexPharma | APOBECs | Somatic mosaicism 💻🔬|🇭🇷|⛷
Jul 20, 2022 • 12 tweets • 9 min read
PAPER OUT !! 🎉🥂🍾 @Nature

nature.com/articles/s4158…

Viral restrictor APOBEC3A is a major cause of mutational signatures found in >50% of cancers + more, Tweetorial👇

With @J_Maciejowski

Via WGS/251 cancer clones (available!)

@broadinstitute
@MSKCancerCenter
@sangerinstitute Image The APOBEC family of cytosine deaminases has been implicated as a source of some of the most prevalent mutational signatures in cancer. BUT, causal links between endogenous APOBECs and mutations in cancer haven’t been established, leaving the mechanisms poorly understood. Image