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Mark R Cookson (he/him/his) Profile picture
Mark R Cookson (he/him/his)
@MarkRCookson1
Scientist interested in neurodegeneration and aging. All views/posts are my own.
Aug 8, 2022 • 12 tweets • 6 min read
Please RT! I'm proud to tell everyone that the iPSC Neurodegenerative Disease Initiative #iNDI that I've been leading with @wardm50 is a physical entity as of today so let me explain why this is a huge deal: jax.org/jax-mice-and-s… Why did we do this? Part of the idea for #iNDI came from experiments we did introducing mutations associated with age-dependent neurodegenerative diseases in the same background IPSC line, here sciencedirect.com/science/articl…
Jul 27, 2022 • 11 tweets • 3 min read
It's out: our paper implicating neuroinflammation as a causal contributor to Parkinson's disease. A 🧵 to explain
Association of a common genetic variant with Parkinson’s disease is mediated by microglia science.org/doi/10.1126/sc… We did these experiments because the LRRK2 gene is associated with both inherited and sporadic Parkinson's disease. In inherited disease we have coding variants that enhance function and there are drug trials aimed at reversing this increase. But...what we didn't know for sure is