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Matt Meizlish Profile picture
Matt Meizlish
@MattMeiz
Yale MD/PhD student - Medzhitov Lab. MPhil History & Philosophy of Science. Scientist, not-yet-physician, believer in a more equitable health care system.
Jan 23, 2021 • 16 tweets • 8 min read
1/ Happy to share our study just out in American Journal of Hematology tinyurl.com/yxa9wots examining in-hospital mortality in COVID-19 patients treated with aspirin or intermediate-dose anticoagulation. A great collaboration between @YaleMed & @dfcidatascience 2/ One of the striking early observations in COVID-19 was that patients suffer from surprisingly high rates of thrombosis, including venous thromboembolism (e.g. PE), arterial thrombosis (e.g. stroke), and microvascular thrombosis in the lungs that may contribute to hypoxemia
Sep 3, 2020 • 15 tweets • 12 min read
1/n For my first tweet (!) excited to share this work by an amazing team of physicians & scientists: bit.ly/3jFvuZr
Punchline: Neutrophils are central to the pathogenesis of severe COVID-19.
Neutrophil granule proteins like Resistin predict critical illness and mortality 2/n There is an emerging consensus that damage from the immune system drives the most severe manifestations of COVID-19. Macrophages are an important player; otherwise, the nature of this immune response is still murky. To gain some deeper insights…