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Prof. Michael Lin Profile picture
Prof. Michael Lin
@MichaelLinLab
Stanford Neurobiology and Bioengineering Precision molecular design / synbiochem. Also @michaelzlin
Sep 20, 2024 • 29 tweets • 9 min read
Super-excited to reveal our latest fluorescent voltage indicator, ASAP5, now online @NeuroCellPress!

ASAP5 features higher responsivity and kinetics, allowing detection of single synaptic transmission events.

The link gives free access until 2024.11.09:
authors.elsevier.com/a/1joYd3BtfH9B…Image To create ASAP5, amazing graduate student Alex Hao developed a biophysical model for how mutations on the voltage-sensing domain influence kinetics and shift voltage sensitivity, then rationally mutated 20 sites, finding an optimized combination of 5 mutants. Image