Mitochondrial Psychobiology. Bridging the science of energy and the human experience to create Healing Science. Upcoming book: ENERGY (2027).
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One of the most intriguing finding is this: 
ERP Assumption 1
GDF15 is an energetic stress marker generally measured in blood. The higher it is, the higher the risk of developing multiple chronic illnesses. 
The basic hypothesis is that there are systemic factors - genetics, behaviors, diet, etc - that likely drive some people to have more or less mitochondria across the whole body
Every tissue expresses GDF15 at some level, whereas the receptor is only or mostly at appreciable levels in the brainstem
Latest example of a hair completely depigmented (grey) returning to its youthful dark color after over a year 
In physical/mechanical systems, excessive resistance and dissipative loss drive information loss
There are many more UPregulated than DOWNregulated proteins associated with loneliness
Multiple mechanisms allow cells to share mitochondria
This hypermetabolism/energy constraint model contrasts with the central dogma model of ATP deficiency as the driver of disease. 
This matters because in humans, chronic stress results in "allostatic load", a dysregulated state associated with functional decline and increased mortality. @n_bobba_alves and @sturm_gav wanted to understand the cellular basis of this phenomenon with @Dr_Epel and colleagues
First thing to recognize is that we tend to look at mitochondria (and most things) with a narrow perspective often blind to the whole, leading to correct but limited observations about parts of the system. We need more integrative perspectives. 
