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https://twitter.com/Muller_Lab/status/1331089662648217601This gets at the phenomenon of threshold toxicity in metabolic toxicity/diseases.
https://twitter.com/trendscancer/status/1321125361602695168Many normal tissues, like bone marrow and gut cells are actually more proliferative than even the most aggressive cancers. E.g. pro-myelocytes have a doubling time of around 17 hrs whilst even aggressive epithelial tumors double every 2-3 weeks or so.