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Nicholas Boyd-Gibbins, MEng, PhD Profile picture
Nicholas Boyd-Gibbins, MEng, PhD
@NBoydGibbins
UCL | Kyoto Univ. | CSO | cell engineering, cell therapy, autoimmune, long Covid, iPSCs, regenerative and predictive medicine, cancer, genetics and neuroscience
Nov 26, 2023 • 10 tweets • 4 min read
This data is from a clinical trial in the US using vagus nerve stimulation to treat POTS

The study used low-level transcutaneous stimulation delivered by an ear-mounted device for 1 hour per day over a 2-month period Image Although the data is not presented, they also report observing a reduction in anti-autonomic autoantibodies α1-AR and β1-AR Image
Oct 17, 2023 • 9 tweets • 3 min read
People with long Covid have reduced serotonin levels

This new collaborative study from the US in Cell has some amazing data

First, this figure shows the relative abundance of metabolites. Serotonin was among the most depleted in the LC cohort, with KP metabolites increased This figure shows the differential expression of different metabolites between long covid patients and healthy controls, with serotonin among the most depleted and Kynurenine pathway metabolites among the most increased The above data was from thousands of patients from several metabolomics studies, but for this study, they then focused on cohorts of LC patients and healthy controls

Before showing that data I thought this was interesting, this data shows non-Covid viruses depleting serotonin This figure shows the study design to test non-Covid viruses effect on reducing serotonin on the left, and the measured reduction on the right
May 28, 2023 • 5 tweets • 2 min read
This data is I think one of the most important findings in ME/CFS and ME/CFS-like long Covid research

It shows that the S1 spike protein subunit can cause mitochondrial fragmentation, part of the "mitochondrial pathogen response"

mdpi.com/2073-4409/12/6… Image We know that spike can persist long term even in the absence of viral RNA and nucelocaspid, meaning that it may just be very stable in the human body. I think it would be fantastic to make testing for S1 protein routine in LC patients

biorxiv.org/content/10.110…