#ESMO24 Round Up: 11 articles were simultaneously published in NEJM and presented at this year’s @myESMO Congress in Barcelona, Spain. Most of the articles included a podcast with NEJM Group editors discussing the significance of the trial results. @myESMO Durvalumab after Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer (ADRIATIC)
📄 Full article: nej.md/4d0eZ5m

Immunoglobulin light chain (AL) amyloidosis is a rare disease that occurs when a plasma cell disorder produces monoclonal light chains, which misfold and are deposited as fibrils in organs or tissues. Read the full review: 1/6

#MedTwitter nej.md/4eHjGU3
The signs and symptoms, treatment approach, and prognosis are highly variable and dictated by the nature of an individual patient’s unique light chains. 2/6

Cannabis is a broad term that can refer to a specific plant, the chemicals contained in the plant, their synthetic counterparts and analogues, and products derived from any of these things.

Read the full review of cannabis-related disorders: 1/15 nej.md/3ToIhoe
The cannabis plant contains more than 500 identified chemicals, many of which are not well characterized pharmacologically, including more than 125 phytocannabinoids. 2/15

A balance between procoagulants and anticoagulants underpins hemostasis.

Science behind the Study: 1/10

#hematology nej.md/3QZxlfQ
Hemophilia, a form of disrupted hemostasis, is caused by dysfunctional variants in genes encoding the procoagulant factors VIII (causing hemophilia A) and IX (causing hemophilia B). 2/10

Metastatic #ColorectalCancer is treated with fluorouracil-based combination chemotherapy with oxaliplatin, with or without irinotecan.

Read the Science behind the Study: nej.md/3VnWj8L 1/15 Inhibitors of vascular endothelial growth factor (VEGF), such as bevacizumab, or epidermal growth factor receptor (EGFR) (for patients without activating RAS variants) are sometimes also included. 2/15

As athletes with concussion recover, several tests typically guide a multistage return-to-play protocol and eventual clearance to return to sport participation.

Read the Correspondence on recovery time after athletic concussion: nej.md/44qmdNh 1/7

#SportsConcussion The rate at which athletes return to preinjury levels of functioning across commonly evaluated domains remains unclear. 2/7

Science behind the Study:

#GastricCancer is a common and often lethal cancer that, like cervical and liver cancer, can be attributed in large part to an infectious cause.

Full editorial on gastric cancer risk available here: nej.md/3JQQY4v 1/15 In the case of gastric cancer, the infectious agent is a bacterium, Helicobacter pylori. Until now, hereditary forms of gastric cancer were thought to be limited to a small percentage of CDH1-mutant cases. 2/15

The recent release of ChatGPT and other artificial intelligence tools have put a spotlight on this developing topic. This thread explores the history of AI in medicine, clinical uses of AI and machine learning, and the use of chatbots. Full article: nej.md/3nt4zHH 1/24 As computers and the concept of artificial intelligence (AI) were almost simultaneously developed in the 1940s and 1950s, the field of medicine was quick to see their potential relevance and benefit. 2/24

The specialty of #CriticalCare has achieved important advances in survival for many patients with the most complex disorders. Along with these advances, however, there has been an increasing awareness of the complicated and persistent morbidity that follows critical illness. 1/10 Episodes of critical illness result in multidimensional acquired or exacerbated conditions that may persist for years after the critical illness and may not be wholly reversible. Health inequities may worsen these outcomes. 2/10

Ventricular fibrillation and sudden death triggered by a blunt, nonpenetrating, and often innocent-appearing blow to the chest without damage to the ribs, sternum, or heart (and in the absence of underlying cardiovascular disease) constitute an event known as commotio cordis. 1/9 A March 11, 2010, Review Article in NEJM focuses on the clinical profile, proposed mechanisms, and prevention and treatment of commotio cordis. Read the free article: nej.md/CommotioCordis 2/9