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https://twitter.com/LFeldmanBarrett/status/16215229783654072331. Localization of function and context independence of functional selectivity are not "assumptions” but empirical hypotheses. It does not advance science to replace them with opposite assumptions (as LFB proposes). Rather, we should test these hypotheses against data.
Kariko pursued her ideas about the medical applications of mRNAs for decades against all odds, with almost no funding or recognition.