BREAKING:
Scientists just ran the first-ever clinical trial of creatine in Alzheimer’s patients.
Brain creatine went up.
Memory and thinking improved.

But the same supplement FAILED a 5-year, 1,741-patient Parkinson’s trial in 2015.
What changed?
What does this mean for brain energy?
A thread on the most fascinating story in brain energy research right now. 🧵🧪

#Alzheimers #Parkinsons #Creatine First: why does creatine even make sense for the brain?

Your brain is an energy hog. Your neurons are always energy-hungry.
They run on ATP.
Creatine = your brain’s emergency battery pack.
It rapidly regenerates ATP when demand spikes.

In both Parkinson’s and Alzheimer’s, this energy system breaks down.
Mitochondria fail. Neurons starve.

#BrainHealth #Mitochondria

🚨 BREAKING Scientists may have just cracked the code on Alzheimer's and Parkinson's — WITH ONE PILL.

A drug called Buntanetap was just published in a peer-reviewed journal with Phase 3 data.
Phase 3 means that we are on the verge of FDA approval.

It targets the ROOT CAUSE of both diseases simultaneously.

Here's what you need to know 🧵👇
#Alzheimers #Parkinsons Tweet 2
Most people think Alzheimer's and Parkinson's are totally separate diseases.
They're not.

At autopsy, ~1 in 3 Alzheimer's patients have Lewy body (Parkinson's-type) protein in their brain.

And ~50% of Lewy body dementia patients have full Alzheimer's pathology too.

Same brain. Multiple diseases. Quietly overlapping. 🧠
That's called co-pathology — and it's why targeting just one protein may never be enough. 👇
#Dementia #Neurodegeneration

🚨 Scientists just identified a hidden 'molecular switch' that drives chronic brain inflammation in Alzheimer’s.

It’s a protein called STING that gets chemically stuck in the “on” position.

This could be a major new drug target. Thread 👇 From Scripps Research
published April 2026, highlighted again recently

In Alzheimer’s brains, STING undergoes a specific chemical modification (S-nitrosylation) → this keeps microglia (brain immune cells) in chronic overdrive, damaging neurons and synapses.

We've spent decades hunting for "the ALS cure."

I get it … when you're facing this disease, you want one answer. That's human.

But after 20 years in neurodegeneration, I can tell you: we've been asking the wrong question.

And new science proves it. Here's what's actually going on.

#ALSAwareness #PrecisionMedicine Here's what I mean.

ALS … amyotrophic lateral sclerosis … is the name we give to a disease where motor neurons die.

But the biological reason they're dying? That differs from patient to patient.

Same diagnosis, but completely different machinery … breaking down underneath.

That's the part nobody told patients. And it matters more than almost anything else in ALS right now.

🚨 BREAKING:
Parkinson's disease may begin in your GUT — not your brain.

Peer-reviewed science now shows gut changes can precede motor symptoms by 10–20 YEARS.

And a deficiency in specific B vitamins may be driving the damage.
Thread 🧵👇 Before the tremors. Before the diagnosis.

Researchers consistently find these GI symptoms in people who later develop Parkinson's:
❌ Chronic constipation
❌ Delayed stomach emptying
❌ Bacterial overgrowth (SIBO)
❌ 'Leaky gut.'

This isn't a coincidence. It's the disease.

🚨 BREAKING Scientists just gave 15 people a single IV drip.
No daily pills.
No monthly injections.
One time.
Done.

Their "bad" cholesterol dropped 50%.
Triglycerides dropped 55%.

And it may be PERMANENT.

This is CRISPR — and it just changed cardiology forever. 🧵 The drug is called CTX310.
It's made by CRISPR Therapeutics.

Here's how it works in plain English:
Your liver makes a protein called ANGPTL3.
That protein BLOCKS your body from clearing cholesterol.

CTX310 turns that gene OFF.
Permanently.

Like flipping a switch — and never having to flip it again. 🔬

BREAKING: Scientists gave 20 patients a single cancer treatment.

All 20 had ZERO detectable cancer cells afterward.
None progressed.
None died.
This just published in Nature Medicine.

Here's what it actually means 🧵👇 The treatment is called CAR-T cell therapy.
Here's how it works:
→ Doctors take YOUR own immune cells
→ Re-engineer them in a lab to hunt cancer
→ Infuse them back in ONE single dose
Your own immune system becomes the weapon.
(2/10)

BREAKING: An AI just designed a drug that restored motor function in Parkinson's disease models.

The FDA cleared it for human trials in January 2026.
This is not sci-fi.
This is happening NOW.
Thread 🧵👇

#Parkinsons #AIinMedicine #NLRP3 Parkinson's Disease in numbers:
• 2nd most common neurodegenerative disease
• 25 MILLION projected cases by 2050
• Current drugs? They only MASK symptoms • Levodopa — the gold standard — was developed in the 1960s
However science is growing and the landscape geared towards Parkinson’s is moving forward.
I explained this in April 2026 with a master landscape highlighting over 200 clinical trials.
There true genuine hope for Parkinson’s!!👇
x.com/Neuroscope_mp/…
#Parkinsons #Neuroscience

BREAKING:
New clinical trials show NAD+ supplements can SLOW the loss of walking speed and grip strength in people over 65.

Your body makes less NAD+ every decade after 40.

These trials show you can get it back.

Thread below 👇 NAD+ is the molecule your cells use to make energy.

By 60 you have roughly half what you had at 20.

NMN and NR are the two supplements being tested to restore it.

Both are forms of Vitamin B3.
Both are taken as a pill or powder.
Both have human clinical trial data.

That's the whole idea. Here's what the science shows 👇

🚨 BREAKING:
Scientists just found a SPECIFIC sugar molecule made by gut bacteria that appears to TRIGGER ALS and dementia.

70% of ALS/FTD patients had it.
Only 33% of healthy people did.

And they found a way to STOP it. 🧵 Published January 2026 in Cell Reports.

Case Western Reserve University researchers spent years tracking why people with the same ALS gene sometimes get the disease — and sometimes don't.

The answer was hiding in their gut the whole time. 👇

BREAKING 🚨 Scientists are clearing 'zombie' cells from the brain to STOP Alzheimer's.

The first clinical trial just proved that the drug reaches the brain.
Phase 2 is underway now.

This is one of the most exciting AD trials in decades.
A thread 🧵↓ First, what is a 'zombie cell'?
In science: a SENESCENT CELL.
It stops dividing. But refuses to die.

Instead, it leaks toxic chemicals — attacking your brain 24/7.

As we age, they pile up.
In Alzheimer's patients? They pile up even faster. 🧠⚡

🚨 BREAKING: Scientists found a protein in your brain that protects against Alzheimer's AND Parkinson's — and almost nobody knows it exists.
It's called BDNF.

What you do every day is either destroying it or building it.

But … The era of BDNF clinical trials and therapy has also begun.

This thread could change how you think about your brain. 🧵👇 BDNF = Brain-Derived Neurotrophic Factor.
Think of it as fertilizer for your brain cells.
✅ Grows new neurons
✅ Repairs existing ones
✅ Powers learning & memory
✅ Regulates mood
✅ Protects motor control

It's critical for BOTH memory AND movement — which is why it matters for Alzheimer's AND Parkinson's. 🧠

BREAKING: 1 in 5 Parkinson's patients carries a genetic variant silently driving their disease.

Most have never been tested.

For the first time in history, trials are being designed specifically for their genetic subtype.

There are now 20+ trials across 6 distinct genetic strategies in active human testing.

Here is the full map.

Thread below. Save this one. First, the biology. You need this to understand why the trials exist.

Parkinson's starts with a protein called alpha-synuclein.

In healthy brains, it folds correctly, does its job, and gets cleared.

In Parkinson's, it misfolds, clumps into toxic masses called Lewy bodies, and spreads from neuron to neuron, killing them as it goes.

What most people don't know:

For millions of patients, a GENETIC MUTATION is the engine that starts this process.

LRRK2 mutation -> kinase stuck ON -> lysosomes fail -> alpha-synuclein accumulates
GBA1 mutation -> GCase enzyme fails -> lysosomes back up -> alpha-synuclein accumulates
SNCA duplication -> too much alpha-synuclein produced from birth

Same toxic protein. Different upstream genetic engine.

Which means: the drug that works for your subtype may not work for someone else's.

People in their 80s and 90s with the memory of 30-year-olds.

They’re called Super Agers — and a major 2026 study just found their brains are literally growing way more new neurons.

Here’s what’s going on. Normal aging shrinks the hippocampus — your memory center.

But SuperAgers?

Their hippocampus is the same size or bigger than that of people decades younger.

BREAKING: Scientists just injected a Parkinson's patient with neurons grown from their OWN skin cells.

No immune drugs. No donor. No rejection.

12 months later — the cells are ALIVE, producing dopamine, and patients are moving better.

This is a thread you need to read 🧵👇

🔗 SOURCE: Aspen Neuroscience Press Release — March 18, 2026
aspenneuroscience.com/aspen-neurosci… First — why does Parkinson's happen?

Your brain has a region called the substantia nigra.
It makes dopamine.
Without it — tremors, rigidity, loss of control.

By the time you're diagnosed, 60–80% of those neurons are GONE.

Current drugs only replace the dopamine temporarily.
They don't replace the neurons.

BREAKING: Milk and yogurt both come from cow's milk.
One has been consistently linked to higher Parkinson's risk in large population studies.

The other may actually be protective.

Same source ... Completely opposite effects on your brain.

Here is what the science actually shows — and why the difference matters. 🧵 THE MILK EVIDENCE
Higher milk intake has been one of the more consistently observed dietary signals in Parkinson's research — appearing across multiple large, independent cohorts.

Key studies:

The Honolulu Heart Program (8,006 men, 30-year follow-up):
Men drinking more than 2 glasses of milk per day showed up to 2x higher PD risk than non-drinkers.
Published: multiple analyses through 2002-2005.

A 2024 meta-analysis of 9 studies and 634,000+ participants:
Milk intake is associated with a ~13% increased PD risk.
Total dairy is associated with a ~21% increased risk.
Published: Public Health (2026).

Most studies show a modest 10-20% increased risk — not a dramatic effect.
But the signal is consistent. And it is specific to milk, not all dairy.

pmc.ncbi.nlm.nih.gov/articles/PMC11…
pubmed.ncbi.nlm.nih.gov/41544344/

BREAKING

By the time a doctor diagnoses Parkinson's disease,
50-80% of dopamine neurons are already gone.

That is the problem biomarkers are trying to solve.
Here is where we actually stand — and it is more hopeful than you think.

🔗 michaeljfox.org/parkinsons-bio… For 14 years, there has been ONE FDA-approved test to help diagnose Parkinson's.

It is called the DaTscan — approved in 2011.

What it does:
+ Shows dopamine transporter loss in the brain
+ Helps rule out essential tremor vs Parkinson's

What it cannot do:
- Cannot tell you WHY neurons are dying
- Cannot diagnose stage or predict progression

It is a start. But the next generation of tests is here.
🔗 drugs.com/history/datsca…
🔗 practicalneurology.com/diseases-diagn…
🔗 movementdisorders.ufhealth.org/2012/04/11/sho…
🔗 davisphinneyfoundation.org/blog/datscan/

BREAKING: Scientists may have found the first treatment that actually slows Parkinson's disease — and it costs $0.

It's not a drug.
It's not a surgery.

It's exercise.
But not just any exercise.

The TYPE and INTENSITY matter enormously.
Here's what the clinical trials actually show 🧵 First — what's actually happening in Parkinson's disease?
Deep in your brain, a region called the substantia nigra is slowly losing dopamine-producing neurons.
Less dopamine = less motor control.

Result: tremor, rigidity, slowness of movement, difficulty walking.
No drug has yet been proven to STOP this loss.
Until now, maybe.

🚨 BREAKING: Scientists in China grew brain cells in a lab, implanted them into Parkinson's patients, and saw real dopamine come back.

Now the FDA has approved this therapy for Phase 1 in the US.
This is XS-411.

And it might be the most important stem cell story you haven't heard.
🧵 Thread 👇 THE PROBLEM — Why Parkinson's is so hard to treat

First — understand what we're dealing with.
Parkinson's = the slow death of neurons deep in your brain that make dopamine — the chemical controlling movement.

Every drug we have just mimics the missing dopamine.
None of them replaces the cells that are gone.

That's the gap XS-411 is trying to close. 👇

BREAKING 🧵
60% of Americans silently carry a virus in their nervous system.
New research suggests it may be slowly giving them Alzheimer's.
This is the most important brain story you haven't heard.
🧵 Thread 👇 Here's the setup.
HSV-1 — the cold sore virus — doesn't leave your body after infection.
It retreats into your nervous system and hides.
For life.
For most people, it stays dormant.
But stress, illness, or aging can wake it up.
And when it does... your brain may pay the price.
pubmed.ncbi.nlm.nih.gov/28644417/
pmc.ncbi.nlm.nih.gov/articles/PMC34…

BREAKING:

Scientists gave healthy older adults a transplant drug once a week.

Their immune systems got younger.
Their flu vaccine worked 20% better.
Side effects? Nearly zero.

This is the most exciting anti-aging drug in human history.

Here's what the clinical trials actually show 🧵 Rapamycin was discovered in the soil of Easter Island in 1972.

It blocks a protein called mTOR — the master switch that controls how fast your cells age.

Turn mTOR down → cells live longer, clean themselves better, age more slowly.

It's already FDA-approved. It's been used safely for decades in transplant patients.

The question was: does it work in healthy aging humans?