Harshi Peiris, Ph.D. Profile picture
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Mar 31 13 tweets 9 min read
BREAKING 🧵
60% of Americans silently carry a virus in their nervous system.
New research suggests it may be slowly giving them Alzheimer's.
This is the most important brain story you haven't heard.
🧵 Thread 👇 Here's the setup.
HSV-1 — the cold sore virus — doesn't leave your body after infection.
It retreats into your nervous system and hides.
For life.
For most people, it stays dormant.
But stress, illness, or aging can wake it up.
And when it does... your brain may pay the price.
pubmed.ncbi.nlm.nih.gov/28644417/
pmc.ncbi.nlm.nih.gov/articles/PMC34…Image
Mar 30 12 tweets 9 min read
BREAKING:

Scientists gave healthy older adults a transplant drug once a week.

Their immune systems got younger.
Their flu vaccine worked 20% better.
Side effects? Nearly zero.

This is the most exciting anti-aging drug in human history.

Here's what the clinical trials actually show 🧵 Rapamycin was discovered in the soil of Easter Island in 1972.

It blocks a protein called mTOR — the master switch that controls how fast your cells age.

Turn mTOR down → cells live longer, clean themselves better, age more slowly.

It's already FDA-approved. It's been used safely for decades in transplant patients.

The question was: does it work in healthy aging humans?
Mar 29 9 tweets 8 min read
🚨 BREAKING: Scientists just injected engineered immune cells DIRECTLY INTO THE BRAIN — and watched glioblastoma tumors shrink.

Two independent teams. Two top journals.
Penn Medicine. Nature Medicine.
Mass General. New England Journal of Medicine.

Patients from each trial have now been alive with NO disease progression for nearly 2 years.

Here's why this changes everything and why this is a massive deal 🧵
nature.com/articles/s4159…
nature.com/articles/s4159…
nejm.org/doi/full/10.10… Glioblastoma is the most common primary brain cancer in adults.

Median survival after diagnosis: 12-18 months.
After it comes back (recurrence)? 6-8 months.

Surgery. Radiation. Chemo. Immunotherapy. Two decades of clinical trials.

All failed.
Mar 28 9 tweets 7 min read
BREAKING:
A molecule from scorpion venom can make cancer cells glow in real-time during surgery.

It's currently in a pivotal trial for children's brain tumors.
Surgeons can now SEE the exact edges of tumors — including deadly invisible margins they used to miss.


This is real. It's in human trials. Thread 🧵👇pmc.ncbi.nlm.nih.gov/articles/PMC44… Here's the problem surgeons face:
In brain surgery, cancer cells and healthy brain tissue look almost identical under a normal light.
Cut too little → cancer comes back. Cut too much → you damage the brain. Permanently.
Surgeons have been operating partially blind for decades.
Until now.
Mar 25 10 tweets 7 min read
BREAKING: Celiac disease affects roughly 1% of the global population.
Tens of millions of people.

The only treatment available to every single one of them?
Don't eat bread.

No drug. No cure. Just a permanent diet —
That, for many, still isn't enough.

Scientists just changed the equation.
And they did it by borrowing logic from cancer research.

Here's what happened 🧵 THE DISEASE
Most people think celiac is a food intolerance.

It isn't.
It's an autoimmune disease.

When someone with celiac eats gluten, their immune system
doesn't just react — it attacks.

It targets the lining of the small intestine.
Over time, it destroys it.

Nutrient absorption. Gone.
The gut lining. Gone.
For some patients — even on a strict diet — it never fully heals.Image
Image
Mar 22 11 tweets 6 min read
🚨 BREAKING:

German researchers treated 15 severe lupus patients with CAR-T therapy.
All 15 went into complete remission.
Many stopped ALL medication.

Now a larger trial just confirmed it — across 3 autoimmune diseases.

This might be the biggest shift in autoimmune medicine in decades. 🧵 Lupus is a disease where your immune system loses its mind.

It stops recognising your own body.
And starts attacking it.

Kidneys. Heart. Joints. Skin. Brain.

5 million people worldwide live with it.
No cure exists.
Most patients are on immunosuppressants for LIFE — just to stop their body destroying itself.

Until now, the best medicine could do was slow it down.
Mar 21 8 tweets 7 min read
BREAKING: A randomized clinical trial just found that Ozempic
(semaglutide) significantly reduces alcohol cravings and heavy
drinking in people with alcohol use disorder.

This isn't about weight loss.

It's about rewiring the brain's reward system.

This changes everything we thought we knew about addiction. 🧵
jamanetwork.com/journals/jamap…
👇 The science is wild. Thread: Here's what the JAMA Psychiatry trial actually found:

🔬 48 adults with alcohol use disorder
⏱️ 9-week randomized, placebo-controlled trial
💊 Low-dose semaglutide vs placebo

Results:
✅ Significant drop in alcohol CRAVING
✅ Reduced drinks per drinking day
✅ Less heavy drinking vs placebo

The authors called it 'initial prospective evidence.'
Translation: This is real. And it's just the beginning. 👇
jamanetwork.com/journals/jamap…
pubmed.ncbi.nlm.nih.gov/39980336/
Image
Mar 20 11 tweets 5 min read
🔴 BREAKING: A cancer immunotherapy just put autoimmune disease into complete remission.
No drugs.
No symptoms.
Immune system: reset.
Lupus 15/15 Remission.

Now scientists are asking: Could this work for Type 1 diabetes?

🧵 Thread CAR-T therapy works like this:
→ Scientists take your own immune cells
→ Reprogram them in a lab
→ Inject them back
→ They hunt and destroy a specific target

This technology wiped out cancers that had no other treatment.
Now it's being pointed at something else entirely.
Mar 18 9 tweets 5 min read
BREAKING: For the first time in 100+ years, Alzheimer's may not be permanent

Scientists just reversed advanced Alzheimer's in mice by restoring brain energy balance, eliminating both plaques AND cognitive decline

The drug worked in two different animal models, suggesting "this could translate to humans".

Game-changing!!

sciencedaily.com/releases/2025/…

cell.com/cell-reports-m… For over 100 years, Alzheimer's has been treated as a one-way decline.
No reversal.
No recovery.
Just slow deterioration.
Every drug trial has focused on slowing it down.

None have asked: can we actually REVERSE it?
Until now. 👇
Mar 10 10 tweets 6 min read
BREAKING: Scientists just gave two old, cheap drugs to MS patients — a hay fever pill and a diabetes tablet — and measured something no drug has ever shown before.

Signs of actual nerve repair.

Not slowing the attack.
REPAIRING the damage.

Here's the science behind it 🧵 Quick background — because this matters.
MS destroys myelin: the protective sheath around your nerve fibers.

Think of myelin like the plastic coating on an electrical wire.

Lose it → signals slow, distort, or stop → disability.

For 50 years, every MS drug has only tried to stop the immune attack.

None could rebuild the coating that was already gone.
Mar 2 10 tweets 5 min read
Hook 🚨BREAKING: German researchers treated 15 severe lupus patients with CAR-T therapy.

All 15 went into complete remission.
Many stopped ALL medication.

This might be the biggest shift in autoimmune medicine in decades. 🧵 What is lupus?
Lupus is a disease where your immune system attacks your own body.
Joints. Kidneys. Heart. Skin.

Millions suffer. There is no cure.
Most patients are on immunosuppressants for LIFE — just to manage symptoms.
Feb 28 12 tweets 7 min read
🚨 BREAKING:
Scientists used a next-gen cancer drug called Rapalink-1 and accidentally discovered a hidden aging mechanism nobody knew existed.

And your gut bacteria are right in the middle of it.
This changes how we think about aging at a cellular level.

🧵 Here's what they found 👇 The drug is Rapalink-1.
It's a third-generation TOR inhibitor — originally built to fight cancer.

But researchers at Queen Mary University of London used it to ask a different question:

👉 What happens to aging when we use it to suppress a master cellular switch called TOR?
The answer surprised everyone.
Feb 22 6 tweets 3 min read
BREAKING: Scientists may have just cracked the code on treating leukemia at HOME.
A new study published in Lancet Haematology shows AML (blood cancer) can now be treated with a pill —
no hospital,
no IV drip,
no infusion chair.
Here's why this is a big deal 🧵👇 The Cool Science Bit
The reason this pill works is genuinely clever 🧠

Normally this chemotherapy drug gets DESTROYED in your gut before it even reaches your blood.

Scientists found a way to block that — so now a simple tablet delivers the exact same dose as an IV infusion.
Patient wins. Science wins.