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Nicholas Ashton Profile picture
Nicholas Ashton
@NicholasAshton
Neuroscientist in Dementia @ University of Gothenburg 🇸🇪 and King's College London 🇬🇧
Jan 25, 2021 • 5 tweets • 6 min read
I am delighted to share our latest blood biomarker work published in @alzassociation.

We investigated baseline & longitudinal #pTau, #NfL, #GFAP, #tTau, #Aβ to predict diagnosis & grey matter changes in individuals not predetermined by CSF/imaging.

alz-journals.onlinelibrary.wiley.com/doi/full/10.10…

1/n Image 2 - While all biomarkers were significantly changed in AD – only #pTau181 had a good accuracy in predicting AD dementia (AUC=0.91).

#pTau181 and #NfL were increased in MCI as compared to CU, and #pTau181 significantly increased in MCI converters versus non-converters ImageImage