Chemical Synthetic Biologist @MRC_LMB | PhD Student @Cambridge_Uni
Oct 13, 2022 • 13 tweets • 8 min read
Proud to announce that my first first-author paper is online! We (@Taylor_Lab_Cam, @PhilHolliger and our co-workers) demonstrate how a novel engineered polymerase unlocks efficient synthesis and evolution of therapeutic 2'-modified nucleic acids.
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Almost twenty nucleic acid therapeutics have been approved for use in the clinic. Antisense oligos are synthesised by solid-phase synthesis, which is efficient but costly, limited to short oligomers and hard to scale up to large numbers of sequence or chemistry variants. (2/n)
