Enormous Midwestern outbreak of H5N1 that so devastated poultry in Ohio & Indiana over past few months is whole NEW genotype, ⭐D1.3⭐ that USDA & CDC just "forgot" to tell us about! (despite HUMAN case)
New D1.3 has swapped American NA of D1.1 for N1 from A3.
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Further to above Post...
Hogvet51 sounds delighted too by this excellent information sharing about D1.3 by USDA & CDC.
Without him & Henry Niman, I wouldn't have know about this...
@JusDayDa
@MegCattell
@KinCONN
@RanuDhillon
@AbraarKaran
@BrusJulian 2/3
Finally got around to testing some Flu-A/B RAT's readily available in UK/EU using A/Texas/37/2024 (B3.13) recombinant Nucleoprotein from Sinobiological, which is nearly identical (99.5%) to D1.1 NP (e.g. 52H/Y difference).
More commentary tomorrow...
@BrusJulian
@RickABright
Slightly earlier photo:
Feb 17 • 15 tweets • 4 min read
Influenza Nucleoprotein (NP) in context of RAT detectabilituly: how do worldwide H5N1 virus NP's compare to current US ones?
pBLAST comparing some NP's of *human* H5N1 cases in past decade to B3.13 (more details of what's being compared later).
@BrusJulian
@RajlabN
@HNimanFC 1/x
Below is rest of H5N1 NP sequence lemgth, and here is where/when samples were from:
0) Texas B3.13 (WYN03023.1) 1) Chile 2023 (B3.2?) 2) China 2010 3) China 2015 4) India 2021 5) Cambodia 2013 6) Bangladesh 2011 7) Vietnam 2012 8) Egypt 2014 9) Hong Kong 10) Canbodia 2011
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Feb 8 • 5 tweets • 1 min read
Attempt to summarise USDA Report with less techno-babble:
A second type of H5N1 Bird Flu has been found in several herds of Nevada cows.
Super bad-boy A-list mutation 627K that lets virus infect mammals is NOT present, but virus *does* have important B-list mutation 701N.
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This means the new H5N1 virus in cows has a head start on infecting humans compared to the virus coming straight from birds.
The amount of head start is similar to that of the "traditional" 2024 cow virus, so human infections from raw milk are likely with new virus too.
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