Professor, MD American physiologist who explores molecular mechanisms of sodium-potassium balance, hypertension & kidney disease || He/Him
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Apr 16, 2019 • 7 tweets • 2 min read
the @thebyrdlab asks for a brief explanation of the potassium switch. What follows is a view of our Research Network, @HibpK
1/The Renal potassium switch provides one mechanism to explain the mysterious effects of potassium on BP. Its existence was first suggested when mutations in WNK kinases were identified as a cause of a genetic intolerance to Na+ and K+ (Gordon syndrome, Familial HyperkalemicHTN.
Jan 20, 2019 • 34 tweets • 6 min read
The Aldosterone Paradox, and the Potassium Switch.
A Tweetutorial:
Aldosterone has paradoxical actions: It increases salt reabsorption in states of circulatory volume (CV) depletion without significantly altering potassium balance. Yet, it also increases potassium excretion in states of potassium without altering sodium balance, or CV.
