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EM Pearl Profile picture
EM Pearl
@PearloftheWeek
Bringing you informative Pearls in Emergency Medicine. Tweets are not medical advice #physicians #residents #nurses #RTs #pharmacists #EMS #students
Aug 13, 2022 • 12 tweets • 5 min read
Today's pearl is about Salicylate☠️!

Toxicity is most often seen with acetylsalicylic acid (Aspirin), but also methyl salicylate (Oil of Wintergreen- 5 mL = 22 aspirin), bismuth subsalicylate (Pepto-Bismol), teething gels, & headache preparations (BC Powder) ingestion
🧵1/11 - Mechanism of Action:
Uncouples oxidative phosphorylation & ↑Renal NaHCO3 excretion➡️AG Metabolic Acidosis
Stimulates medullary 🫁 drive ➡️ 1° respiratory alkalosis

- Clinical: Tinnitus, N/V, Tachypnea/Hyperpnea, AMS & Hyperthermia (late)➡️⚠️RAPID DECOMPENSATION
🧵2/11