Hot-of-the press sub-analysis of ADVOR trial looking at HCO3 levels and decongestive response @ESC_Journals #EHJ. A short 🧵 on the rational, findings and clinical translation of the paper. @FH_Verbrugge , @WilfriedMullens , @AlexMebazaa , @kevin_damman

doi.org/10.1093/eurhea… The rational= old forgotten concept (fig). AT II stimulates prox nephron Na/HCO3. Exact stoichiometry might differ but per Na retained +/- 3 HCO3 are retained. HCO3 levels can indicate neurohormonal activation. HCO3 levels can predict development of HF (pubmed.ncbi.nlm.nih.gov/25896890/ )