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Radek Nowak Profile picture
Radek Nowak
@RPNowak
Engineer and biochemist. Working on targeted protein degradation at Dana-Farber Cancer Institute. Tweets are my own.
Jul 20, 2021 • 10 tweets • 5 min read
Pleased to share our story on Structure-Guided Design of a “Bump-and-Hole” Bromodomain-Based #Degradation Tag: BRD4-BD1-L94V #BromoTAG
We combine it with #dTAG to show simultaneous protein depletion!
@DrXiongY @kdonovan1008 @Nicky_eleuteri @fischerlab1
pubs.acs.org/doi/10.1021/ac… XY-06-007 is a structure based designed CRBN degrader, which binds to BRD4 BD1 L94V and has limited affinity to BRD4 BD1.