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Jan 15 10 tweets 3 min read
Recent research shows blood from people with ME/CFS and Long COVID directly harms healthy muscle, reducing force, stressing mitochondria, and causing structural breakdown. Results implicate blood-borne drivers of muscle weakness, exertion intolerance, and PEM, and introduce a non-invasive lab model that mirrors push-crash dynamics.

🔗 doi.org/10.1088/1758-5…Title: Muscle tissue exposed to blood from ME/CFS & Long COVID patients leads to severe muscular and mitochondrial deterioration.  Image of muscle tissue deteriorating.  Site sourced at the bottom: https://doi.org/10.1088/1758-5090/adf66c  Arrow pointing to swipe right Description of the Study  Researchers exposed 3D healthy human skeletal muscle tissues to serum (a component of blood) from people with ME/CFS, Long COVID, or healthy donors and watched how the muscle tissue functioned/changed over the course of 48, 96, or 144 hours of exposure to the serum.   Exposing tissues to patient serum allowed the researchers to see the impact of patient blood components on healthy muscle tissue in a controlled environment without potentially confounding factors such as physical deconditioning from reduced activity.   The contractile profile (tissue health) of the m...
Dec 10, 2025 6 tweets 2 min read
A new RECOVER study of 6.4M health records shows Long COVID risk has not decreased from 2020–2024. Incidence stayed stable across variants, reinforcing Long COVID as an ongoing public health priority.
Read the study: doi.org/10.1093/cid/ci…New Study:  Long COVID Risk Has Not Decreased Over Time  Image of a virus  (Arrow pointing right) Small Citation  Description of the Study  As part of the National Institutes of Health (NIH)–funded Researching COVID to Enhance Recovery (RECOVER) Initiative, study authors leveraged electronic health record (EHR) data from three large clinical research networks to estimate Long COVID incidence over time.    Researchers analyzed EHR data from 6.4 million records across 2020–2024. They tested several definitions of Long COVID and also a single “harmonized” definition aligned with National Academies guidance to compare results.   The study included adult and pediatric patients with documented acute SARS-CoV...
Aug 1, 2025 6 tweets 3 min read
A new study by @moriahphd et.al. finds that babies whose mothers had COVID-19 during pregnancy are at increased risk of developmental delays.

Cognitive, communication, and motor delays were linked to changes in cytokines and chemokines found in umbilical cord blood—pointing to possible biomarkers for early intervention.

COVID-19 during pregnancy may have significant negative implications for child development.

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Full study: doi.org/10.1038/s41390…

#PregnancyAndCOVID #ChildDevelopment #Neurodevelopment #COVID19 #MaternalHealth #LongCOVID #Pediatrics #PublicHealth #EarlyIntervention #RTHMNew Study:  SARS-COV-2 infection in pregnant women is linked to developmental delays in toddlers  (Photo of a pregnant woman with a cold) Description of the Study  This study aimed to evaluate the impact of maternal infection on neurodevelopment and investigate whether cytokine and chemokine profiles predict delays at 24 months.  Conducted in Brazil (January 2021–March 2022), this follow-up study included 18 SARS-CoV-2 positive pregnant women at 35–37 weeks’ gestation, 15 umbilical cord blood samples, and blood samples from 15 children at 6 months and 14 at 24 months.  Developmental delay was defined using the Bayley Scales of Infant and Toddler Development, Third Edition, with scores below 90 in cognitive, communication, or ...
Jul 16, 2025 9 tweets 3 min read
A new NIH RECOVER study followed hundreds of children under 6 and found that up to 15% met criteria for probable Long COVID—many with symptoms lasting over a year.

Distinct symptom patterns were seen by age group. Poor appetite, chronic cough, sleep issues, and fatigue were strongly linked to prior COVID-19 infection.

The authors estimate nearly 6 million U.S. children may be affected by Long COVID — surpassing Asthma as the most common chronic condition in kids today.

If you think your child may be showing signs of Long COVID, @JAMANetwork Pediatrics created a resource to help you prepare: 🔗 jamanetwork.com/journals/jamap…

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🔗 DOI: 10.1001/jamapediatrics.2025.1066

@RachelGrossMD @tthaweethai @DrLarryK

#LongCOVID #PediatricLongCOVID #LongCOVIDKids #MEcfs #Pediatrics #ChronicIllnessAwareness #COVID19 #RTHM #MedicalResearch #MCAS #POTS #PEM #PESEImage Image
Jun 30, 2025 9 tweets 3 min read
A new study suggests that exercise doesn’t clear microclots in people with Long COVID—it just fragments them into smaller ones. These smaller clots are linked to increased inflammation and impaired oxygen transport, which may help explain post-exertional malaise (PEM) and post-exertional symptom exacerbation (PESE)—a worsening of symptoms after even mild physical or mental effort.

Researchers observed these microclot and inflammatory changes even after submaximal exertion, highlighting the need for caution when recommending exercise-based therapies.

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🔗 DOI: doi.org/10.21203/rs.3.…

#LongCOVID #ChronicFatigue #pwLC #PostCOVID #rthm_health #LongCOVIDResearch #PESE #PEM #IACC #COVID19 #MicroclotsExercise Increases Microclots In Long COVID.    (Arrow pointing right) Picture of someone exhausted on an exercise bike Description of the Study  46 people living with Long COVID with a low risk of experiencing post-exertional malaise (PEM) completed two submaximal cardiopulmonary exercise tests (CPET), separated by 24 hours.  They had blood drawn before starting the exercise test (CPET) and after, to look for microclots and cytokines.
Jun 9, 2025 8 tweets 2 min read
A new study from New Zealand found that over one-third of university students experienced measurable cognitive deficits—especially in executive function—up to 17 months after COVID-19 infection.

Even in a young, healthy population, the impacts on brain function were objectively detectable using neuropsych testing and brain oxygenation data.

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🔗 DOI: 10.1016/j.bbi.2024.12.002

#LongCOVID #ChronicFatigue #PostCOVID #rthm_health #LongCOVIDResearch #CognitiveDysfunction #BrainFog #IACC #COVID19New Study:  37% of undergrads experienced cognitive impairment up to 17 months after COVID-19 infection  (Arrow pointing right) young person sleeping on pile of books Key Findings:  The study investigated whether past COVID-19 infections influence cognitive performance in undergrads from University of Otago (New Zealand) by measuring neuropsychological performance, and cerebral haemodynamics (brain blood flow and oxygenation) using NIRS.     40% of participants in the COVID group reported brain fog due to COVID-19 (subjective cognitive impairment).   37% of participants in the COVID group exhibited objective cognitive impairment in at least 1 cognitive task (mainly related to executive functions).   NIRS worn during cognitive testing found differences in...
May 14, 2025 6 tweets 2 min read
New research shows SARS-CoV-2 infection particles can persist in semen for up to 8 months after infection, raising critical questions about viral reservoirs and potential sexual transmission. The virus remained detectable in over half the study participants and was confirmed as infectious through cell culture. While decreased sperm quality showed signs of recovery by 6 months, the implications of viral persistence in the male genital tract remain under investigation.

This study adds to growing evidence that the male reproductive system may serve as an immune privileged site for virus reservoirs, similar to findings in Post-Ebola Syndrome.

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#LongCOVID #ChronicFatigue #PostCOVID #rthm_health #LongCOVIDResearch #IACC #ViralPersistence #COVID19New Study:  “SARS-CoV-2 infectious viral particles detected in semen for up to 8 months after infection.”    (Arrow pointing right) with an image of a man sitting on a bed looking down with his hands clasped at his thighs   Key Findings:  SARS-CoV-2 RNA was detected in the semen of 55% (21/38) of the patients, with a higher detection rate in the moderate (acute severity) group (91%).  Viral persistence was confirmed through Vero cell culture in 47% (17/38) patients, with infectious viral particles detected for up to 8 months after infection.    (Arrow pointing right) Small Citation
Apr 24, 2025 7 tweets 2 min read
Even Olympic athletes aren’t bouncing back from COVID.

A new study out of Germany found that nearly 40% of elite athletes across several sports had reduced performance lasting >4 months after acute COVID-19. This was despite the majority having mild acute infections and none of the athletes having pre-existing health conditions.

Fatigue, shortness of breath, and pain were common, persisting symptoms, indicating a need to change current return-to-play protocols for athletes.
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#LongCOVID #ChronicFatigue #PostCOVID #rthm_health #LongCOVIDResearch #IACC #OlympicGames #OlympicsNew Study:  40% of Olympians experienced reduced sports performance for at least 4 months after COVID infection.    (Arrow pointing right) Picture of an olympian out of breath? In a study aimed to describe the impact of SARS-CoV‑2 infection on sports performance in elite athletes, researchers found the following:  37% reported symptoms lasting > 4 weeks  25% had symptoms persisting for > 8 weeks  20% were still symptomatic 16 weeks after initial infection.
Jan 30, 2025 12 tweets 4 min read
We’re excited to announce RTHM Direct is now offering Ivabradine. We’ve seen this medication make a significant difference for patients with #LongCovid, #POTS, & #MECFS — and are excited to expand its access. Here’s everything you need to know 👇🧵 What Is Ivabradine?

It is an FDA-approved medication designed to reduce heart rate without affecting blood pressure that works by slowing the activity of the “pacemaker cells” in the heart. It specifically reduces heart rate without lowering blood pressure.
Dec 13, 2024 6 tweets 2 min read
Is #LongCovid a national security issue?

The CHARM 2.0 study conducted reveals striking findings about Long COVID’s impact on even the fittest among us. Among 899 young, healthy Marines, nearly 25% developed Long COVID, with lasting effects on productivity, physical fitness, and overall performance—despite most having mild initial infections.
Swipe to learn more about this pivotal study and why Long COVID must remain a public health priority.

Find the full study here: thelancet.com/journals/lanam…

#LongCOVID #COVID19 #pwLC #pwME #MECFS #IACC #StaySafe #rthm_healthA new study finds 1 in 4 US Marines Infected with COVID Have Long COVID a Year Later Findings:   The study enrolled 899 otherwise young, healthy US Marine participants, and 88.8% had a SARS-CoV-2 infection.   Almost a quarter (24.7%) of the infected individuals developed Long COVID, and had significantly decreased physical fitness test scores up to approximately one year post-infection.  https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(24)00236-9/fulltext