Assistant Dean of Research and Associate Professor, NYITCOM at Arkansas State University | My Tweets are my own
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Jan 6 • 4 tweets • 2 min read
The Louisiana Department of Health reports the patient who had been hospitalized with the first human case of highly pathogenic avian influenza (HPAI), or H5N1, in Louisiana and the U.S. has died.
New @NEJM case report describing severe human illness caused by highly pathogenic avian influenza A -H5N1 in #BritishColumbia (#Canada) teenager with evidence of potential viral adaptation to humans.
1/n nejm.org/doi/full/10.10…
A 13-year-old girl with mild asthma and obesity (BMI >35) presented with conjunctivitis, fever, respiratory distress, and multi-organ complications was hospitalized on 11/7/24, and required intensive care, including ECMO and continuous renal therapy
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Dec 22, 2024 • 4 tweets • 1 min read
#H5N1 #AvianInfluenza updates
Quick analysis of the 7 sequences from NIAID experimental study of #Macaques infected w/ H5N1 2.3.4.4b (B3.13 type)
KP.3.1.1* is still the top circulating group of lineages in the world.
This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 08/08/2024 (12,884 sequences)
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Sep 1, 2024 • 5 tweets • 2 min read
What the XEC!
Recombinant #SARSCoV2 lineage #XEC (recombinant of KS.1.1/KP.3.3) has the potential to outcompete other circulating lineages in #USA (and other countries)
More data is needed to provide a reliable growth advantage estimates
KP.3.1.1* is the top circulating group of lineages in the world. This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 07/25/2024 (14,688 sequences)
KP.3.1.1 is the top circulating lineage in the world. This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 07/11/2024 (15,325 sequences)
This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 06/27/2024 (12,753 sequences)
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Jul 26, 2024 • 6 tweets • 3 min read
#H5N1 Updates #AvianInfluenza
@USDA #APHIS #NVSL has submitted 211 sequences on 7/24/24 with collection dates in 01 to 06/2024
12 #cow milk seqs from #Minnesota with **PB2 Q591R** in addition to the cattle outbreak signature M631L [isolate ID 24-016288-001 to 015!]
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PB2 Q591R: A basic amino acid at position 591 of PB2 can compensate for the lack of lysine at position 627 and confers efficient viral replication to pandemic H1N1 viruses in mammals.
A total of 1886 sequences were submitted with specimen collection dates on or after 04/04/2024 (of which 373 (~19.8%) were collected via airport surveillance)
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Apr 28, 2024 • 6 tweets • 2 min read
#H5N1 #LessonLearned - Domestic and Farm cats!
Common theme among H5N1 clade 2.3.4.4b infected Cats:
- Present multiple symptoms almost immediately
- Neurologic, Respiratory, rapid decline leading to death
(or compassionate euthanasia)
- Pick PB2 mammalian adaptations
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French Cat (2022)
Phylogenetic analysis linked the infection closely to virus circulating in the neighboring duck farm, with minor genetic differences.
Key mutations: PB2 E627K & NS: E26G
Again, rapid selection of mammalian adaptation mutation
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A total of 1509 sequences were submitted with specimen collection dates on or after 03/16/2024 (of which 69 (~4.6%) were collected via airport surveillance)