Time really does *fly* by when you’re enjoying journal club🪰

This week we discussed the newly released Aging Fly Cell Atlas by @TzuChiaoLu, @mariabrbic, @HongjieLi5, @StephenQuake and colleagues!

doi.org/10.1101/2022.1… This valuable new resource provides insights into the changes in cellular composition and transcriptional patterns across the whole animal during the aging time course of Drosophila, and provides an understanding of cell-type specific aging features.

New preprint! 🥳

biorxiv.org/content/10.110…

Led by @aledjohnparry & @ChristelKrueger we asked why #DNAmethylation and oxidation often target overlapping genomic regions at the exit of #pluripotency.

Great collaboration with @Tim_Lohoff, @StevenWingett & @stefanschoenfe1.

🧵👇 Excellent work by @SchubelerLab, @rulandsgroup, Jaenisch lab, Meissner lab, @CarellThomas and others has shown that DNA methylation turns over genome wide as cells exit naïve pluripotency, especially at enhancer elements.

We discussed this here: rdcu.be/b8bfM

Now published in @eLife! 🎉 We show that transient iPSC reprogramming can substantially rejuvenate human fibroblast cells (many markers suggest by about 30 years)! Congratulations to @Diljeet_Gill who led the work. Thread below 👇🧵
elifesciences.org/articles/71624 During the process, which we call maturation phase transient reprogramming (MPTR), we express the Yamanaka factors (OSKM) in fibroblast cells for 10-17 days (until the "maturation phase") before removing their expression and allowing the cells to revert back.