Gʀᴇɢᴏʀʏ Rɪᴇʟʏ Profile picture
Medical Oncologist at Memorial Sloan Kettering Cancer Center. Clinical focus on patients with lung cancer and thymic malignancies
Apr 10, 2019 10 tweets 4 min read
THREAD: (1/10) Our work in JCO PO looked at NGS data from patients with met lung adeno. Some goals: (1) explore notion of molecular staging (within stage IV) using somatic mut & (2) see what drives poorer outcomes under current standard of care ascopubs.org/doi/full/10.12… #MSKIMPACT (2/10) We knew some single-gene mutations were good (e.g. EGFR, ALK) or bad predictive/prognostic determinants. OncoCast helped broadly explore effect of genes & gene combinations using an ensemble statistical learning strategy