@boulware_dr @JAMA_current How to do a hatchet job in Ivermectin for COVID-19: first, start with a study of mild illness and low risk patients. All should do well, so intervention will show no benefit. @boulware_dr @JAMA_current Use a modest number of patients, not enough to show significance with small differences.

Use time to symptom resolution, since all are expected to recover. Do not use viral clearance, which would be more likely to give a statistically significant result. Ignore long Covid.