Ryan Marino, MD Profile picture
Human Doctor • Toxicology • Addiction • Emergency • #WTFentanyl & more often just WTF • drugs are misunderstood but people are misunderstood more • he/him
Jun 5 5 tweets 2 min read
“American people would really like to know the answer,” and the question was literally, “What if I buy ten guns and I shoot them all and miss, can I buy 500 more guns for my collection?” But I’m actually more concerned that the answer wasn’t hey, well, actually if an individual is purchasing 500 guns then there is some sort of flag or added security check in place cause that’s 250x more guns than most people even have hands to hold them
Jan 22 4 tweets 2 min read
Omg shut up already you ignorant hypocrite
Katya displays her “new favorite wine” The people who oppose harm reduction are literally the most ignorant people alive. For starters, they oppose reducing preventable harms.
Jan 5 4 tweets 3 min read
Unsurprising response given Alison’s increasing level of bias against harm reduction. Unserious person and unserious publication. If you want to put personal opinions on the front page that contradict an entire body of evidence then at least acknowledge the person’s financial COI
I asked the account representing the journal for Alcoholism and Drug Abuse Weekly why they’d platform someone without acknowledging they had a financial conflict of interest and were espousing views contradicted by evidence
The journal/Alison Knopf blocked me
Keith Humphreys makes 6 figures from the pharmaceutical company that produces some of the only available/approved medicines for treatment of addiction and known for market manipulation/profiteering. He also frequently spreads unscientific misinformation. npr.org/2023/06/02/117…
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Jun 28, 2023 5 tweets 2 min read
In case you forgot who RFK’s favorite “medical expert,” Sherri Tenpenny is, she’s the one who said COVID vaccines ‘contain nanoparticles that use quantum entanglement technology to create trans humans & give people an IP address to connect to the D matrix’ It’s just basic physics, you guys
Jun 19, 2023 4 tweets 1 min read
Since antivaxxers refuse to stop regurgitating this blatant lie, let me clarify:

Thalidomide was not FDA approved in the United States until 1998 -was never an approved or prescribable drug before then- and only then for leprosy & later cancer (it was never allowed in pregnancy) Thanks to *a scientist* (the incredible Frances Oldham Kelsey) who correctly reviewed the data and found it inadequate for safety. She assessed the available trials as low quality. She is a hero and it was because she was an expert at science and interpreting scientific data.
Jun 17, 2023 10 tweets 2 min read
Lyme Disease has increased significantly in recent years as climate change allowed for its tick carriers to spread & survive overwinter. Why don’t we have a vaccine for this relatively straightforward bacterial infection? Well, we did. But antivaxxers killed it. A provaxx thread: LymeRix was FDA approved in 1998. It had a measured 75% efficacy after a 3-dose regimen over 12 months. This is pretty good. I’d definitely take 75% over 0%. But back then Lyme was more isolated to small pockets in the Northeast and “easily treatable” with 4+ weeks of doxycycline
Jun 14, 2023 4 tweets 1 min read
How do you treat acute poisoning with diet, exercise and sleep? My whole profession could learn so much from this - checks notes - “health coach!” If someone tells you that doctors don’t care about your diet, sleep and exercise then they probably don’t have any actual knowledge or understanding of the entirety of medicine…and they’re probably trying to sell you their “alternative”
May 16, 2023 4 tweets 1 min read
I remember the day the first COVID patient who had needed a ventilator got discharged from my hospital. It took them so long. And they were still incredibly debilitated from the virus. But everybody was excited because we all needed that little bit of hope after weeks of horrors. Everybody in the entire healthcare system wanted COVID patients to avoid ventilators and we literally had overhead celebrations and parades when they got off of the ventilators. These were also televised so even if you weren’t there you should remember. The contrarians are ghouls
May 16, 2023 6 tweets 2 min read
If you see these kind of claims going around please know that there is absolutely no data that shows this and anyone who says so is either intentionally lying or just incapable of interpreting the data. The data, the paper, and the authors do not say anyone died from ventilators. Image Intubation to go on a ventilator is an invasive medical procedure which requires consent (from the pt) or emergency circumstance like respiratory failure so bad it isn’t responding to other treatments & a pt so sick they are unable to consent & others aren’t able to be contacted.
May 15, 2023 7 tweets 3 min read
Really disturbing that a brand new third year medical student is name calling and insulting one of the greatest living scientists and continuously promoting a repeatedly-debunked conspiracy that hospitals killed COVID patients on purpose not the COVID virus that killed millions… Kevin Bass insults Dr. Pete...Kevin Bass promotes a debun... He also posts anti-trans and pro-eugenics stuff in between selling medical consultations and promotional codes for supplements (threaded)
May 14, 2023 5 tweets 2 min read
300 Americans died preventable deaths today bc they only had access to unsafe supply. Their family & friends are left to suffer.

When you see propagandists posting this stuff please ask why they think “diverting” safe supply (to ppl who don’t want to die) is worse than ppl dying “Diversion” is well studied & when it comes to lower potency (ie safer) drugs than what is widely available (eg fent) the reason people buy on the black market is almost always because they cannot access these evidence-based treatments otherwise. Bc safe supply is not accessible!
Apr 14, 2023 9 tweets 4 min read
I take a lot of flak for publicly disagreeing w/ people on here. I stick to what I know. In light of the recent murder Michelle Tandler disgustingly capitalized on to push a false narrative I am sharing our DMs from Feb 2022 & you can decide if she genuinely wants to learn & help To be clear, if you DM me in good faith I will try to respond & will treat your question as private. This person is not acting in good faith & I think people should know that I explained things to her in calm, painstaking detail over a year ago & she has only become more extreme. ImageImage
Apr 13, 2023 5 tweets 4 min read
Regular reminder that this person has not even started third year of med school, never treated a single patient let alone a COVID patient, and never done research in any areas even remotely related to COVID, masks, oxygenation & ventilation, etc.

He does sell products online tho Image Would love to know how to “optimize cognition” through curated keto diet recipes for $1000/month Image
Apr 3, 2023 4 tweets 2 min read
Not to make things weird because I love you guys and am definitely already weird enough, but I’ve had a really terrible several months/years in most aspects of my life & I just want to thank this community here for always being supportive & always reminding me what is important. I learn from you all way more than I have anything to share. And the way that people lift each other up, lift strangers up, and share the knowledge they have to better others gives me so much hope. Good things do happen and that’s not just what I want to believe but what I know.
Mar 25, 2023 4 tweets 1 min read
Large “nonprofit” health systems continue to report financial strain, citing increased labor costs, supply costs, and lower reimbursements.

An analysis of 10 large systems found that false, with poor finances driven primarily by private investment losses. healthaffairs.org/do/10.1377/for… When losses are driven by risky financial investments, which generated positive returns in previous years & will do so in future periods, it does not make sense that patients, employees and taxpayers should be responsible for paying to offset the impact of overall market declines
Mar 24, 2023 4 tweets 2 min read
Definitely in the running for the most cringe online person Image It’s banger after banger from this guy ImageImage
Mar 21, 2023 6 tweets 2 min read
The adderall shortage was manufactured by DEA & is maintained by DEA. They limit the manufacturers and set the quotas. When one manufacturer has a problem (as has happened) they don’t make any contingency plan for what is a life-improving and life-sustaining medicine for millions Also worth noting that when they set quotas for controlled substances a year in advance they are supposed to take prescribing rates/numbers into account. In 2021 they decided they didn’t believe the prescriptions were legitimate. Despite having no medical arm, medical staff, etc.
Mar 19, 2023 4 tweets 1 min read
This is their next move: pretending dogs are being harmed. This dog had no symptoms and its handler still squirted Narcan up its nose and took it to an emergency vet on taxpayer $. Dogs also don’t overdose just from touching or being near fentanyl. And they have 10x the tolerance If I’m being honest I haven’t reviewed sci papers for quite a few months because of personal stuff that isn’t important. But some of the best work I’ve ever done was getting a lot of dog “fentanyl exposure” stuff rejected bc it’s fucking bunk. From like Homeland Security no less!
Feb 7, 2023 9 tweets 2 min read
Let’s talk about the risk of secondhand fentanyl smoke…a thread 🧵

First, it’s not really “smoking” because if you combust fentanyl you get noxious chemicals with no opioid effect. So it’s really vaporization (or pyrrolysis) at low temperatures (direct flame would destroy it). People do “smoke” (vape/inhale) fentanyl. It’s a pretty common way to use, especially outside the US but seems to be increasing here. It is actually considered a harm reduction method (and prescribed in some places) because it prevents damage to veins and other risks of injection
Nov 16, 2022 4 tweets 1 min read
I spend my time trying to stop fentanyl overdoses & could not be a bigger champion of the benefits of vaccines…

This ain’t it. This is not going to be a solution to fentanyl overdoses.

Meanwhile, we have existing solutions that get ignored for out-of-touch moonshots like this. Many people have shared concerns for a vaccine that blocks valuable medicines in addition to potential for cross reactivity to other molecules. Piperidine derivatives are quite ubiquitous.

But people who overdose unintentionally still use drugs intentionally. They deserve safety
Mar 20, 2021 10 tweets 2 min read
Recently had a patient who was really suffering from very miserable opioid withdrawal after stopping heroin (on top of some other unpleasant things) tell me their family had convinced them not to start buprenorphine (suboxone) therapy because “it’s just legal heroin”

A thread... So we have a condition associated with human suffering and also associated with high rates of death.

For those against drugs, know that untreated withdrawal is a big driver of recurrent drug use.

And we have old, evidence-based medicines that treat withdrawal. Why not use them?