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Sarah Aitken Profile picture
Sarah Aitken
@S_J_Aitken
Group Leader @aitken_lab @MRC_TU @Cambridge_Uni • Consultant Pathologist @CUH_NHS • phenotypes to genotypes via genomic pathology • tweets≠employer
Jun 24, 2020 • 14 tweets • 12 min read
We are really excited that our work showing how pervasive lesion segregation shapes cancer genome evolution is published today in @nature.

nature.com/articles/s4158…

Here’s a #tweetorial to explain our #LesionSegregation findings...

[1/13] Human cancer genomes are unavoidably confounded by genetic and environmental differences. Such intrinsic heterogeneity hinders our ability to disentangle biases of DNA damage and repair. So we used an in vivo oncogenesis model to re-run cancer evolution hundreds of times.
[2/13]
Dec 9, 2019 • 11 tweets • 7 min read
We are really excited to share our work on how Pervasive lesion segregation shapes cancer genome evolution @biorxivpreprint.

Here’s a #tweetorial to explain our #LesionSegregation findings...
biorxiv.org/content/10.110…
Thread, 1/11 Human cancer genomes are unavoidably confounded by genetic and environmental differences. Such intrinsic heterogeneity confounds our ability to disentangle biases of DNA damage and repair. So we used an in vivo oncogenesis model to re-run cancer evolution hundreds of times.
2/11