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Herbert B Schiller Profile picture
Herbert B Schiller
@SchillerLab
Professor at Ludwig-Maximilians-University (LMU) @LMU_Muenchen Institute of Lung Health and Immunity @HelmholtzMunich German Center for Lung Research (DZL)
Jan 17, 2023 • 20 tweets • 10 min read
[1/20] Modeling disease directly in human tissue slice cultures transforms mechanistic studies as well as drug development and translation. A thread on our new work @biorxivpreprint.

bit.ly/3H9LTnr

Two amazing first authors: @niklasjlang @schniering_j
@HelmholtzMunich [2/20] Our previous work showed that Regenerative Intermediate Cell States (RICS) transiently appear after lung injury but persist in lung fibrosis patients:

bit.ly/3X7AQ3T

In this work we induce such RICS in human precision cut lung slices (hPCLS).
Feb 19, 2021 • 8 tweets • 4 min read
[1/8] Mass spectrometry for autoantibody profiling of patient body fluids. Pre-print out on @medrxivpreprint - A proteomics workflow reveals predictive autoantigens in idiopathic pulmonary fibrosis. @HelmholtzMunich @labs_mann
Tweetorial below...

bit.ly/3qCTArP Image [2/8] We have previously discovered an unexpected high prevalence of tissue resident MZB1+ plasma cells in lung and skin fibrosis. The number of these cells was associated with lung function decline and tissue IgG in IPF.

bit.ly/3sa9vOx Image