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Sean Pitroda, M.D. Profile picture
Sean Pitroda, M.D.
@SeanPitroda
Radiation oncologist & cancer biologist @UChicago @LudwigCancer investigating oligometastatic disease & interplay between radiotherapy & immunotherapy
Nov 20 • 8 tweets • 2 min read
1/ Our latest - @JAMAOncology Viewpoint! Ablative radiotherapy has a dual effect on metastatic cancer that changes how we should interpret progression after treatment. 2/ Key finding from our @Nature study: Radiotherapy does TWO things simultaneously: ✅ SUPPRESSES new metastatic seeding from treated tumors ⚠️ UNMASKS dormant lesions at distant sites via immune reprogramming

We call this the "badscopal effect."
Oct 8 • 14 tweets • 2 min read
Thread 1/14 🧵
New in @CCR_AACR: Our perspective on amphiregulin (AREG) as both a PREDICTIVE BIOMARKER and THERAPEUTIC TARGET following stereotactic radiotherapy (SBRT) in metastatic cancer.

What makes this clinically actionable? Let's dive in. 2/14

SBRT is increasingly used for oligometastatic disease. While 20-30% achieve durable control, 70-80% eventually progress.

Key question: Can we PREDICT who will progress and INTERVENE to prevent it?

Our @Nature study [PMID: 40369065] identified AREG as a key mediator